Search Results for: Carcinogenic

Abstract: The International Agency for Research on Cancer (IARC) Monographs Programme identifies chemicals, drugs, mixtures, occupational exposures, lifestyles and personal habits, and physical and biological agents that cause cancer in humans and has evaluated about 1000 agents since 1971. Monographs are written by ad hoc Working Groups (WGs) of international scientific experts over a period …

Abstract: Glyphosate is a widely used broad spectrum herbicide, reported to induce various toxic effects in non-target species, but its carcinogenic potential is still unknown. Here we showed the carcinogenic effects of glyphosate using 2-stage mouse skin carcinogenesis model and proteomic analysis. Carcinogenicity study revealed that glyphosate has tumor promoting activity. Proteomic analysis using 2-dimensional …

Abstract: 2,4-Dichlorophenoxyacetic acid (2,4-D) is carcinogenic in male and female rats and probably also in mice. Male and female rats ingesting 2,4-D developed increased incidences of malignant neoplasms. Lymphosarcomas were increased in rats of both sexes, and neoplasms of the mammary gland in female rats. Male rats also had carcinomas of the endocrine organs. 2,4-D …

Abstract: In March, 2015, 17 experts from 11 countries met at the International Agency for Research on Cancer (IARC; Lyon, France) to assess the carcinogenicity of the organophosphate pesticides tetrachlorvinphos, parathion, malathion, diazinon, and glyphosate. Keywords: cancer, carcinogenicity, organophosphate, pesticides, tetrachlorvinphos, parathion, malathion, diazinon, glyphosate, rodent, animal, human Citation: Guyton, K.Z., Loomis, D., Grosse, Y., …

Abstract: Glyphosate is the active ingredient in the pervasive herbicide, Roundup, and its usage, particularly in the United States, has increased dramatically in the last two decades, in step with the widespread adoption of Roundup®-Ready core crops. The World Health Organization recently labelled glyphosate as “probably carcinogenic.” In this paper, we review the research literature, …

Abstract: In June, 2015, 26 experts from 13 countries met at the International Agency for Research on Cancer (IARC; Lyon, France) to assess the carcinogenicity of the insecticides lindane and 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane (DDT), and the herbicide 2,4-dichlorophenoxyacetic acid (2,4-D). These assessments will be published as Volume 113 of the IARC Monographs. Keywords: 2,4-Dichlorophenoxyacetic Acid, Animals, Carcinogens, …

Abstract: Glyphosate is currently the most commonly applied herbicide and its use is still growing. Nowadays, over 50 commercial preparations containing this compound are used, and these formulations are much more toxic than their active compound, glyphosate, owing to the presence of many surfactants and carrier compounds. Toxicological investigations provide evidence that glyphosate is an …

Abstract: Background Glyphosate-based herbicides (GBHs) are broad-spectrum herbicides that act on the shikimate pathway in bacteria, fungi, and plants. The possible effects of GBHs on human health are the subject of an intense public debate for both its potential carcinogenic and non-carcinogenic effects, including its effects on microbiome. The present pilot study examines whether exposure …

Abstract: We recently proposed that deficient cellular interactions in endocrine pancreas were a primary cause for cancer. Normally, insulin secreting beta cells release in parallel GABA, for inhibiting neighboring alpha and delta cells, releasing glucagon and somatostatin respectively. A deficiency of GABA release, will lead to a hybrid anaboliccatabolic metabolism, mediated by insulin and glucagon. …

Abstract: Methods. During the 1980s, the National Cancer Institute conducted three case-control studies of NHL in the midwestern United States. These pooled data were used to examine pesticide exposures in farming as risk factors for NHL in men. The large sample size (n = 3417) allowed analysis of 47 pesticides simultaneously, controlling for potential confounding …

Text: As journalists, we have dug into the controversy over the suspected carcinogenicity of the herbicide glyphosate (see B. Url Nature 553, 381; 2018). We searched hundreds of internal documents from its manufacturer, Monsanto, released for pending lawsuits (see go.nature.com/2tfpbwy). We feel that our and others’ findings (N. Ghisi et al. Chemosphere 145, 42–54; 2016) …

Abstract: In 1977 a number of patients with soft-tissue sarcomas and previous exposure to phenoxyacetic acids were described. Following from these observations a matched case-control study was made. Exposure to chlorophenols was also included in this study. The results showed that exposure to phenoxyacetic acids or chlorophenols gave an approximately 6-fold increase in the risk …

Text: Given a lack of evidence to accurately determine the risks and benefits of genetically modified foods (GMOs), an intense debate continues between its promoters and opponents. Some authors highlight the advantages of consuming GMOs, for example, their ability to address certain needs such as hunger. They also believe non-GMOs have not been sufficiently studied, …

To the editors: The suggestion that “golden” rice, bioengineered to contain Beta-carotene (1), could have a “real impact on the health of children living in Southeast Asia” (2) deserves critical scrutiny from nutrition professionals. This rice, although not yet available commercially, has become the “poster child” of the food biotechnology industry’s extensive public relations campaign …

Abstract: The broad-spectrum herbicide glyphosate (common trade name “Roundup”) was first sold to farmers in 1974. Since the late 1970s, the volume of glyphosate-based herbicides (GBHs) applied has increased approximately 100-fold. Further increases in the volume applied are likely due to more and higher rates of application in response to the widespread emergence of glyphosate-resistant …

Abstract: Context – Among the 134 million hectares of genetically modified plants growing worldwide in 2009, more than 99.9 % are described as pesticide plants (Clive 2009). Around 80 % are tolerant to Roundup, a glyphosate based herbicide. Its use on GMOs is thus amplified, and this phenomenon shed a new light on the problem …

Abstract: Highlights – Glyphosate is found in the respirable dust (RD) emitted by different sources (bulk soil and aggregate-size fractions); Aminomethylphosphonic acid (AMPA) content in the RD is higher than glyphosate contents; Glyphosate and AMPA are found in the RD even 12 months after last glyphosate application; Glyphosate content in RD were from 4 to …

Abstract: Glyphosate, the main ingredient in Roundup®, is the most widely used herbicide in the world. It is also used in combination with another effective herbicide, 2,4-D, in the formulation called Enlist Duo®. The EPA approved the use of Enlist Duo® on certain crops including those genetically modified to be resistant to both herbicides. The …

Abstract: An association between malignant lymphoma (both Hodgkin’s disease (HD) and non-Hodgkin lymphoma) and exposure to organic solvents, phenoxy acids, or chlorophenols was previously reported. A reanalysis of this investigation regarding the cases with HD and exposure to various chemicals was performed and resulted in comparable findings to the whole group of malignant lymphoma. There …

Abstract: A number of men with malignant lymphoma of the histiocytic type and previous exposure to phenoxy acids or chlorophenols were observed and reported in 1979. A matched case-control study has therefore been performed with cases of malignant lymphoma (Hodgkin’s disease and non-Hodgkin lymphoma). This study included 169 cases and 338 controls. The results indicate …

Abstract: The herbicide glyphosate, N-(phosphonomethyl) glycine, has been used extensively in the past 40 years, under the assumption that side effects were minimal. However, in recent years, concerns have increased worldwide about the potential wide ranging direct and indirect health effects of the large scale use of glyphosate. In 2015, the World Health Organization reclassified …

Abstract: 2,4-D is one of the most widely used herbicides in the world. It is commonly used on rangeland and pasture, in the production of wheat, and on home lawns. Symptoms of 2,4-D poisoning in exposed people include irritation and inflammation of eyes and skin, hives, nausea, vomiting, throat irritation, headache, dizziness, coughing, and difficulty …