Search Results for: Endocrine Disruptor
Effect of endocrine disruptor pesticides: a review
Abstract: Endocrine disrupting chemicals (EDC) are compounds that alter the normal functioning of the endocrine system of both wildlife and humans. A huge number of chemicals have been identified as endocrine disruptors, among them several pesticides. Pesticides are used to kill unwanted organisms in crops, public areas, homes and gardens, and parasites in medicine. Human …
The endocrine disrupter effect of atrazine and glyphosate on Biomphalaria alexandrina snails
Abstract: Atrazine (AZ) and glyphosate (GL) are herbicides that are widely applied to cereal crops in Egypt. The present study was designed to investigate the response of the snail Biomphalaria alexandrina (Mollusca: Gastropoda) as a bioindicator for endocrine disrupters in terms of steroid levels (testosterone (T) and 17β-estradiol (E)), alteration of microsomal CYP4501B1-like immunoreactivity, total …
Glyphosate-based herbicides are toxic and endocrine disruptors in human cell lines
Abstract: Glyphosate-based herbicides are the most widely used across the world; they are commercialized in different formulations. Their residues are frequent pollutants in the environment. In addition, these herbicides are spread on most eaten transgenic plants, modified to tolerate high levels of these compounds in their cells. Up to 400 ppm of their residues are …
Adverse health effects to fish caused by endocrine disrupting chemicals (edcs) – literature review and preliminary results on patterns of neuronal activation in the olfactory bulbs of white cachama piaractus brachypomus and hormonal changes in tilapia oreochromis sp. caused by exposures to commercial presentations of glyphosate
Abstract: We present the long-term goals and research activities by collaborators of the ‘fishENCODE’ project, part of the global “ONE HEALTH Epigenomics Educational Initiative” (1). The goals of fishENCODE are to study the intergenerational epigenetic changes and adverse health effects to fish caused by endocrine disrupting chemicals (EDCs) such as the metal cadmium (Cd) and …
Analysis of endocrine disruption effect of Roundup® in adrenal gland of male rats
Abstract: The effect of Roundup® on adrenal gland steroidogenesis and signaling pathway associated with steroid production was investigated. Doses of 10, 50, 100 and 250 mg/kg bw/d Roundup® were administered for two weeks to adult male rats. The 10 mg/kg bw/d dose which reduced circulatory corticosterone levels, but did not change food consumption and body …
Why glyphosate is not the issue with Roundup: A short overview of 30 years of our research
Abstract: Roundup and other glyphosate-based herbicides are the most widely used pesticides in the world; their residues are among the main pollutants in surface waters. Their use has increased through the spraying of 80% of edible agricultural GMOs, which also contain high levels of their residues. They are composed of glyphosate (35–40% in general) and adjuvants …
Perinatal exposure to a commercial formulation of glyphosate reduces the mRNA expression and increases the protein content of beta TSH in the pituitary of male offspring
Abstract: Glyphosate is a broad spectrum herbicide that is effective against weeds, especially in association with transgenic glyphosate resistant crop systems, and represents approximately 30% of all herbicides used in agriculture. It was demonstrated that glyphosate has an activity of endocrine-chemical disruptor (ECD) in the reproductive axis, altering the production of testosterone and causing disturbances …
Dicamba affects sex steroid hormone level and mRNA expression of related genes in adult rare minnow (Gobiocypris rarus) at environmentally relevant concentrations
Abstract: Dicamba is a benzoic acid herbicide that has been detected in surface and ground water. The herbicide has been shown to have cytogeneic and DNA damaging effects and to cause organ damage in mammals; however, little is known about the endocrine disrupting effects of dicamba in fish. In this study, histological changes, plasma vitellogenin …
Obesogens: An emerging threat to public health
Abstract: Endocrine disrupting chemicals (EDCs) are defined as exogenous chemicals, or mixtures of chemicals, that can interfere with any aspect of hormone action. The field of endocrine disruption is historically rooted in wildlife biology and reproductive endocrinology where EDCs are demonstrated contributors to infertility, premature puberty, endometriosis, and other disorders. Recently, EDCs have been implicated …
Agricultural expansion as risk to endangered wildlife: Pesticide exposure in wild chimpanzees and baboons displaying facial dysplasia
Abstract: Prenatal exposure to environmental endocrine disruptors can affect development and induce irreversible abnormalities in both humans and wildlife. The northern part of Kibale National Park, a mid-altitude rainforest in western Uganda, is largely surrounded by industrial tea plantations and wildlife using this area (Sebitoli) must cope with proximity to human populations and their activities. …
Potential toxic effects of glyphosate and its commercial formulations below regulatory limits
Abstract: Glyphosate-based herbicides (GlyBH), including Roundup, are the most widely used pesticides worldwide. Their uses have increased exponentially since their introduction on the market. Residue levels in food or water, as well as human exposures, are escalating. We have reviewed the toxic effects of GlyBH measured below regulatory limits by evaluating the published literature and …
Toxicity of formulants and heavy metals in glyphosate-based herbicides and other pesticides
Abstract: The major pesticides of the world are glyphosate-based herbicides (GBH), and their toxicity is highly debated. To understand their mode of action, the comparative herbicidal and toxicological effects of glyphosate (G) alone and 14 of its formulations were studied in this work, as a model for pesticides. GBH are mixtures of water, with commonly …
The hormonal herbicide, 2,4-dichlorophenoxyacetic acid, inhibits Xenopus oocyte maturation by targeting translational and post-translational mechanisms
Abstract: The widely used hormonal herbicide, 2,4-dichlorophenoxyacetic acid, blocks meiotic maturation in vitro and is thus a potential environmental endocrine disruptor with early reproductive effects. To test whether maturation inhibition was dependent on protein kinase A, an endogenous maturation inhibitor, oocytes were microinjected with PKI, a specific PKA inhibitor, and exposed to 2,4-D. Oocytes failed …
Perinatal exposure to glyphosate-based herbicide alters the thyrotrophic axis and causes thyroid hormone homeostasis imbalance in male rats
Abstract: Glyphosate-based herbicides (GBHs) are widely used in agriculture. Recently, several animal and epidemiological studies have been conducted to understand the effects of these chemicals as an endocrine disruptor for the gonadal system. The aim of the present study was to determine whether GBHs could also disrupt the hypothalamic-pituitary-thyroid (HPT) axis. Female pregnant Wistar rats …
Glyphosate induces human breast cancer cells growth via estrogen receptors
Abstract: Glyphosate is an active ingredient of the most widely used herbicide and it is believed to be less toxic than other pesticides. However, several recent studies showed its potential adverse health effects to humans as it may be an endocrine disruptor. This study focuses on the effects of pure glyphosate on estrogen receptors (ERs) …
Hypothetical link between endometriosis and xenobiotics-associated genetically modified food
Abstract: Endometriosis is an oestrogen-dependant inflammatory disease affecting 10 % of reproductive-aged women. Often accompanied by chronic pelvic pain and infertility, endometriosis rigorously interferes with women’s quality of life. Although the pathophysiology of endometriosis remains unclear, a growing body of evidence points to the implication of environmental toxicants. Over the last decade, an increase in …
Glyphosate impairs male offspring reproductive development by disrupting gonadotropin expression
Abstract: Sexual differentiation in the brain takes place from late gestation to the early postnatal days. This is dependent on the conversion of circulating testosterone into estradiol by the enzyme aromatase. The glyphosate was shown to alter aromatase activity and decrease serum testosterone concentrations. Thus, the aim of this study was to investigate the effect …
Prepubertal exposure to commercial formulation of the herbicide glyphosate alters testosterone levels and testicular morphology
Abstract: Glyphosate is a herbicide widely used to kill weeds both in agricultural and non-agricultural landscapes. Its reproductive toxicity is related to the inhibition of a StAR protein and an aromatase enzyme, which causes an in vitro reduction in testosterone and estradiol synthesis. Studies in vivo about this herbicide effects in prepubertal Wistar rats reproductive …
Concerns over use of glyphosate-based herbicides and risks associated with exposures: a consensus statement
Abstract: The broad-spectrum herbicide glyphosate (common trade name “Roundup”) was first sold to farmers in 1974. Since the late 1970s, the volume of glyphosate-based herbicides (GBHs) applied has increased approximately 100-fold. Further increases in the volume applied are likely due to more and higher rates of application in response to the widespread emergence of glyphosate-resistant …
Lethal and sublethal effects of pesticides on aquatic organisms: the case of a freshwater shrimp exposure to Roundup®
Abstract: In this chapter, the effects of rapid human population growth on aquatic ecosystems are discussed. These effects are seen in such phenomena as climate change, nutrient enrichment of aquatic environments, and pollution by all types of chemicals including pesticides on local, regional and global scales. These anthropogenic disturbances adversely impact the normal functioning of …
