Search Results for: Parkinson
Neuroimaging abnormalities in parkinsonism: Study of five cases
Abstract: We report the brain magnetic resonance (MR) imaging abnormalities observed at the basal ganglia system of 5 patients (2 female and 3 male), who fulfilled the criteria of parkinsonism. The onset of parkinsonian syndrome ranged from 5 to 52 years old. All patients underwent MR exams with a 1.5T MR equipment. High field T2-weighted …
Parkinsonism and related factors among elderly farmers living in a chilli farm area in Hua Rua sub-district, Muang district, Ubonratchathani, Thailand
Abstract: Previous studies had reported that pesticide exposure and various types of pesticides used may cause the symptoms of parkinsonism. To explore the association of parkinsonism in farmers, the risks factors such the demographics and pesticide exposure and pesticide prevention must be studied. 271 participants that consisted of elderly farmers with average of 50 and …
Genetically engineered crops, glyphosate and the deterioration of health in the United States of America
Abstract: A huge increase in the incidence and prevalence of chronic diseases has been reported in the United States (US) over the last 20 years. Similar increases have been seen globally. The herbicide glyphosate was introduced in 1974 and its use is accelerating with the advent of herbicide-tolerant genetically engineered (GE) crops. Evidence is mounting …
Parkinsonism after chronic occupational exposure to glyphosate
Abstract: As a broad-spectrum herbicide employed to kill weeds, glyphosate (N-(phosphonomethyl) glycine) is typically either sprayed to be absorbed through the leaves, injected into the trunk, or applied to the stump of a tree, and is also used to control vegetation around transmission towers, pipelines, water drainage channels, public squares, and streets throughout the world …
Glyphosate pathways to modern diseases V: Amino acid analogue of glycine in diverse proteins
Abstract: Glyphosate, a synthetic amino acid and analogue of glycine, is the most widely used biocide on the planet. Its presence in food for human consumption and animal feed is ubiquitous. Epidemiological studies have revealed a strong correlation between the increasing incidence in the United States of a large number of chronic diseases and the …
Glyphosate, pathways to modern diseases III: Manganese, neurological diseases, and associated pathologies
Abstract: Manganese (Mn) is an often overlooked but important nutrient, required in small amounts for multiple essential functions in the body. A recent study on cows fed genetically modified Roundup®-Ready feed revealed a severe depletion of serum Mn. Glyphosate, the active ingredient in Roundup®, has also been shown to severely deplete Mn levels in plants. …
Glyphosate induced cell death through apoptotic and autophagic mechanisms
Abstract: Herbicides have been recognized as the main environmental factor associated with human neurodegenerative disorders such as Parkinson’s disease(PD). Previous studies indicated that the exposure to glyphosate, a widely used herbicide, is possibly linked to Parkinsonism, however the underlying mechanism remains unclear. We investigated the neurotoxic effects of glyphosate in differentiated PC12 cells and discovered …
Pesticides and human chronic diseases: Evidences, mechanisms, and perspectives
Abstract: Along with the wide use of pesticides in the world, the concerns over their health impacts are rapidly growing. There is a huge body of evidence on the relation between exposure to pesticides and elevated rate of chronic diseases such as different types of cancers, diabetes, neurodegenerative disorders like Parkinson, Alzheimer, and amyotrophic lateral …
Aluminum and glyphosate can synergistically induce pineal gland pathology: connection to gut dysbiosis and neurological disease
Abstract: Many neurological diseases, including autism, depression, dementia, anxiety disorder and Parkinson’s disease, are associated with abnormal sleep patterns, which are directly linked to pineal gland dysfunction. The pineal gland is highly susceptible to environmental toxicants. Two pervasive substances in modern industrialized nations are aluminum and glyphosate, the active ingredient in the herbicide, Roundup®. In …
Human health risks of the use of glyphosate and glyphosate-based herbicides: Review
Abstract: Glyphosate used in genetically modified organism soybean and corn production. Glyphosate can lead health problems in individuals exposed the chemical occupationally and environmentally as well as air, water and food. Glyphosate (N-phosphonomethyl glycine) is a broadspectrum weedkillers (herbicide) widely used all over the world. Glyphosate is inhibited 5-enolpurivilshikimic acid-3-phosphate synthase in the shikimate pathway …
Glyphosate’s suppression of cytochrome P450 enzymes and amino acid biosynthesis by the gut microbiome: pathways to modern diseases
Abstract: Glyphosate, the active ingredient in Roundup®, is the most popular herbicide used worldwide. The industry asserts it is minimally toxic to humans, but here we argue otherwise. Residues are found in the main foods of the Western diet, comprised primarily of sugar, corn, soy and wheat. Glyphosate’s inhibition of cytochrome P450 (CYP) enzymes is …
Occurrence of glyphosate and AMPA residues in soy-based infant formula sold in Brazil
Abstract: Glyphosate is an herbicide widely used in the world, being applied in several crops, among them soybeans. Recently, glyphosate and its metabolite aminomethylphosphonic acid (AMPA) have been identified as possible contributors to the emergence of various diseases such as autism, Parkinson’s and Alzheimer’s diseases, as well as cancer. The child population-consuming cereal-based foods is …
Morus alba leaf extract mediates neuroprotection against glyphosate-induced toxicity and biochemical alterations in the brain
Abstract: Recent studies demonstrate that glyphosate exposure is associated with oxidative stress and some neurological disorders such as Parkinson’s pathology. Therefore, phytochemicals, in particular phenolic compounds, have attracted increasing attention as potential agents for neuroprotection. In the present study, we investigate the impact of glyphosate on the rat brain following i.p. injection and the possible …
Exposure to glyphosate- and/or Mn/Zn-ethylene-bis-dithiocarbamate-containing pesticides leads to degeneration of γ-aminobutyric acid and dopamine neurons in Caenorhabditis elegans
Abstract: Previous studies demonstrate a positive correlation between pesticide usage and Parkinson’s disease (PD), which preferentially targets dopaminergic (DAergic) neurons. In order to examine the potential relationship between two common pesticides and specific neurodegeneration, we chronically (24 h) or acutely (30 min) exposed two Caenorhabditis elegans (C. elegans) strains to varying concentrations (LC(25), LC(50) or …
Exposure to Mn/Zn ethylene-bis-dithiocarbamate and glyphosate pesticides leads to neurodegeneration in Caenorhabditis elegans
Abstract: Epidemiological evidence suggests positive correlations between pesticide usage and the incidence of Parkinson’s disease (PD). To further explore this relationship, we used wild type (N2) Caenorhabditis elegans (C. elegans) to test the following hypothesis: Exposure to a glyphosate-containing herbicide (TD) and/or a manganese/zinc ethylene-bis-dithiocarbamate-containing fungicide (MZ) may lead to neurotoxicity. We exposed N2 worms …
GMOs, gut flora, the shikimate pathway and cytochrome dysregulation
Abstract: Epidemiological studies demonstrate a closely matched rise in the incidence of more than thirty human diseases with the increased utilization of glyphosate, the active ingredient in Monsanto’s RoundUp, and the increased consumption of foreign proteins created by genetically modified plants. More than 140 studies have supported the deleterious effects of glyphosate upon the biome, …
Acute glyphosate-surfactant poisoning with neurological sequels and fatal outcome
Abstract: Clinical picture of severe glyphosate-surfactant poisoning is manifested by gastroenteritis, respiratory disturbances, altered mental status, hypotension refractory to the treatment, renal failure, shock. Single case report indicated possible neurotoxic sequels of glyphosate-surfactant exposure with white matter lesions and development of Parkinsonism. We described a patient with massive white matter damage which led to vigil coma …
Etiology: An editorial on the prevention of communication disorders
Text: To inaugurate this new on-line, open-source journal, I would like to highlight communication disorders in general and their causation in particular. Independent researchers and theoreticians, in my lifetime and throughout the history of science, have valued the discovery, dissemination, and subsequent uptake of ideas that advance knowledge. Unsurprisingly, scientific advances depend on faithful records …
