Search Results for: Placenta

Abstract: The placental passage of three compounds with different physicochemical properties was recently investigated in ex vivo human placental perfusion experiments (caffeine, benzoic acid, and glyphosate) [Mose, T., Kjaerstad, M.B., Mathiesen, L., Nielsen, J.B., Edelfors, S., Knudsen, L.E., 2008. Placental passage of benzoic acid, caffeine, and glyphosate in an ex vivo human perfusion system. J. …

Abstract: Foreign DNA (deoxyribonucleic acid) is part of our environment. Considerable amounts of foreign DNA of very different origin are ingested daily with food. In a series of experiments we fed the DNA of bacteriophage M13 as test DNA to mice and showed that fragments of this DNA survive the passage through the gastrointestinal (GI) …

Abstract: Roundup is a glyphosate-based herbicide used worldwide, including on most genetically modified plants that have been designed to tolerate it. Its residues may thus enter the food chain, and glyphosate is found as a contaminant in rivers. Some agricultural workers using glyphosate have pregnancy problems, but its mechanism of action in mammals is questioned. …

Abstract: We have previously shown that, when administered orally to mice, bacteriophage M13 DNA, as a paradigm foreign DNA without homology to the mouse genome, can persist in fragmented form in the gastrointestinal tract, penetrate the intestinal wall, and reach the nuclei of leukocytes, spleen and liver cells. Similar results were obtained when a plasmid …

Abstract: Glyphosate-based herbicides (GBHs) are the most globally used herbicides raising the risk of environmental exposition. Here, we investigated whether perinatal exposure to low doses of a GBH alters the female reproductive performance, and/or induced second-generation effects related to congenital anomalies or growth alterations. Pregnant rats (F0) received a GBH through food, in a dose …

Abstract: Agricultural genetically modified (GM) plants are essentially plants which contain pesticides, because they were designed to tolerate or produce pesticides. In 2011, GM crops reached 160 million hectares, with 59 % of herbicide tolerance (mainly Roundup) mostly in soybean, maize, canola, cotton, 15 % of insecticide producing varieties and 26% combining both traits (James …

Abstract: Because certain hereditary diseases show autistic behavior, and autism often runs in families, researchers seek genes underlying the pathophysiology of autism, thus core behaviors. Other researchers argue environmental factors are decisive, citing compelling evidence of an autism epidemic in the United States beginning about 1980. Recognition that environmental factors influence gene expression led to …

Abstract: Aromatase is a specific component of the cytochrome P450 enzyme system responsible for the transformation of androgen precursors into estrogens. This enzyme is encoded by the CYP19A1 gene located at chromosome 15q21.2, that is, expressed in ovary and testis, but also in many extraglandular sites such as the placenta, brain, adipose tissue, and bone. …

Text: Introduction. With the advent of introducing genetic engineering in agricultural sciences and food production, food safety has become a major issue.[1] The genetic content of the organisms is altered using these techniques that result into genetically engineered organism (plants/animals) also known as genetically modified organisms. Human beings mainly depend upon plants for their food …

Abstract: Pesticides are always used in formulations as mixtures of an active principle with adjuvants. Glyphosate, the active ingredient of the major pesticide in the world, is an herbicide supposed to be specific on plant metabolism. Its adjuvants are generally considered as inert diluents. Since side effects for all these compounds have been claimed, we …

Abstract: Research purpose. Identify the presence of unidentified factor transgenic soybean in posterity of rats at her long-term feeding. Object and research methods. Research conducted on white rats which were kept in the vivarium Vinnitsa National Medical University named M.I. Pirogov. Two groups of rats by 10 goals each fed a standard diet vivarium and …

To the editor: The authors of the bibliographic review “Developmental and Reproductive Outcomes in Humans and Animals After Glyphosate Exposure: A Critical Analysis” (Williams et al., 2012) tentatively analyzed four of our articles concerning the cellular toxicity and endocrine-disrupting effects of glyphosate (G) – based herbicides (GBH) including Roundup (R) (Gasnier et al., 2009, Richard …