Search Results for: Rats
Histopathological and biochemical changes in liver of rats fed Bt cotton seeds
Abstract: The present study was undertaken to evaluate the effect of feeding Bt and non Bt cotton seeds on the liver of female albino rats. The experimental rats were divided in to three groups viz; control, Bt and non Bt group. They were fed Bt and non Bt cotton seeds at a dose of 2g/kg …
The presence in the offspring of rats unidentified factor transgenic soy at its feeding over several generations
Abstract: Research purpose. Identify the presence of unidentified factor transgenic soybean in posterity of rats at her long-term feeding. Object and research methods. Research conducted on white rats which were kept in the vivarium Vinnitsa National Medical University named M.I. Pirogov. Two groups of rats by 10 goals each fed a standard diet vivarium and …
The influence of regular and genetically modified soybeans on postnatal development of rats
Abstract: Ukraine is one of the European and world leaders in soybean cultivation. According to some estimation, 30-90% of the crops area is used currently for cultivation of genetically modified varieties. As modified soybean areas are expanding, the potential nutritional threats related to this product should be thoroughly assessed. The influence of nutrition ration consisting …
Ion imbalance is involved in the mechanisms of liver oxidative damage in rats exposed to glyphosate
Abstract: Glyphosate (N-phosphonomethyl-glycine, GLP) is the most popular herbicide used worldwide. This study aimed to investigate the effects of glyphosate on rats’ liver function and induction of pathological changes in ion levels and oxidative stress in hepatic tissue. Sprague-Dawley rats were treated orally with 0, 5, 50, and 500 mg/kg body weight of the GLP. …
Analysis of caecal microbiota in rats fed with genetically modified rice by real-time quantitative PCR
Abstract: The effect of genetically modified rice (GMR) on bacterial communities in caecal content was analyzed in a 90-d feeding rat model. A total of 12 groups of rats, which included male and female, were fed with the basal diets containing 30%, 50%, 70% GMR (B(1), B(2), B(3)) or 30%, 50%, 70% non-GMR (D(1), D(2), …
Serum biochemical assessment of hepatic and renal functions of rats during oral exposure to glyphosate with zinc
Abstract: A subchronic toxicity study was carried out to assess hepatic and renal functions of rats during oral exposure to glyphosate with zinc for the period of 8 weeks. Forty-eight Wistar rats used for the study were randomized into six groups of eight Wistar rats each, and each group had equal number of male and …
The Comparative Effects of Genetically Modified Maize and Conventional Maize on Wistar rats
Abstract: Aim: Genetically modified crops have a potential to solve many of the world’s nutrition problems. On the other hand, the impact of these novel crops on environmental, animal and human health should be tested and their risk assessment is required. In this study, the aim of this study was to investigate the positive or …
Ultrastructural characteristic of rats liver of the third generation with the influence of genetically modified and traditional soybean
Abstract: Summary the article discusses the results of electronic microscopic researches of the rats’ liver of the third generation which were fed with the genetically modified and traditional soybean. Object of the research were 42 rats of the Wistar line, weight of 160–180 g, age of 3.5–4 months. Three groups were formed, 14 rats in each …
Postnatal exposure to a glyphosate-based herbicide modifies mammary gland growth and development in Wistar male rats
Abstract: Our aim was to evaluate whether postnatal exposure to a glyphosate-based herbicide (GBH) modifies mammary gland development in pre- and post-pubertal male rats. From postnatal day 1 (PND1) to PND7, male rats were injected subcutaneously every 48 h with either saline solution (vehicle) or 2 mg GBH/kg·bw. On PND21 and PND60, mammary gland and blood samples were …
Reproductive capacity and structural and functional status rats uterus that consumed feed containing 20% GM-soy
Abstract: The article presents the dynamics of changes in female fertility of I, II and III generations of rats and morph functional state of rats uterus of I generation, which were fed with feed containing 20% traditional and genetically modified soy. Received three generations of rats that consumed feed containing 20% of GM and traditional …
Thymus Cortex Thymocytes quantity of the rats fed on genetically modified soybeans
Introduction. Advances in biotechnology have resulted in an increasing number of genetically engineered foods, and, among these, soybean is one of the most widespread. Foods produced through agricultural biotechnology should be assessed for their potential health risks, in particular allergenicity. Thymus provides organism response to foreign substance. There are no enough research dates demonstrating histological …
Efficacy of ascorbic acid in reducing glyphosate-induced toxicity in rats
Abstract: Aim. Humans and animals interact with their environments on a daily basis and, as a consequence, are exposed to a broad spectrum of synthesized chemicals present in the food they eat, the air they breathe and the water they drink including glyphosate. This study was aimed at investigating the effects of glyphosate on the …
Subchronic exposure to kalach 360 SL-induced endocrine disruption and ovary damage in female rats
Abstract: Kalach 360 SL (KL), glyphosate (G) surfactant-based herbicides, is a systemic herbicide effective against weeds. It was applied in agriculture in Tunisia and throughout the world, which can represent a risk to non-target organisms. The aim of this study was to investigate the morphological and biochemical aspects of ovary injury after exposure to KL. …
Conclusion to the report about feeding of rats by genetically modified potatoes Russet Burbank
Abstract: The analysis of the relevant part of the Institute of Nutrition Report showed that the studies were not carried out according to the accepted protocols for the biomedical assessment of GM food and feed (1). Many of the conclusions drawn by the authors do not correspond to the obtained data and therefore they are …
Immunotoxicological studies of genetically modified rice expressing PHA-E lectin or Bt toxin in Wistar rats
Abstract: As part of the SAFOTEST project the immunmodulating effect of Cry1Ab protein from Bacillus thuringiensis (Bt) and PHA-E lectin from kidney bean (Phaseolus vulgaris erythroagglutinin) was examined in 28- and 90-day feeding studies in Wistar rats. PHA-E lectin was chosen as positive control. Rats were fed control rice, transgenic rice expressing Cry1Ab protein or …
Biological effects of transgenic Bt cotton seeds fed in long term reproduction studies in rat
Abstract: The present study was designed to evaluate the impact of feeding a line of genetically modified cotton seeds (Bt cotton seeds) to that of standard diet and reference diet (Non-Bt cotton seeds) on growth, metabolism in albino rats. Non-Bt and Bt cotton seeds were incorporated into the diet of the albino rats at a …
Evaluation of the potential effect of transgenic rice expressing Cry1Ab on the hematology and enzyme activity in organs of female Swiss rats
Abstract: To assess the safety of transgenic rice expressing Cry1Ab protein to vertebrates, the effect of Cry1Ab rice on broad health indicators in blood and various organs of Swiss rats were analyzed. The 30 and 90 day safety studies of Cry1Ab rice on female Swiss rats revealed that Cry1Ab rice had no significant effect on …
Behavioral changes in rats fed a diet containing 2,4-dichlorophenoxyacetic butyl ester
Abstract: Oral administration of 2,4-dichlorophenoxyacetic butyl ester (2,4-Dbe) at a dose of 69 mg/kg/day to nulliparous females had no deleterious effects on either open field (OF) and rotarod performance. By contrast, dams treated with 2,4-Dbe during pregnancy exhibited impairments of OF activity, rotarod performance and improved active avoidance learning (AAL) retention. Administration of 2,4-Dbe to …
BT BRINJAL Event EE1: The Scope and Adequacy of the GEAC Toxicological Risk Assessment. Review of Oral Toxicity Studies in Rats
Abstract: This evaluation of Bt brinjal studies is based on requirements for a rigorous evaluation of food safety for the people of India and their health. Departures from Indian and international published standards for the 14-day and 90-day studies are a cause for concern 1. The current food safety studies for Bt brinjal were not …
Pre- and postnatal toxicity of the commercial glyphosate formulation in Wistar rats
Abstract: Glyphosate is the active ingredient and polyoxyethyleneamine is the surfactant present in the herbicide Roundup formulation commercialized in Brazil. The aim of this study was to assess the reproductive effects of glyphosate-Roundup on male and female offspring of Wistar rats exposed during pregnancy and lactation. Dams were treated orally with water or 50, 150 …
Alternations in the response to kainic acid in rats exposed to glufosinate-ammonium, a herbicide, during infantile period
Abstract: Toxic effects of glufosinate ammonium (GLA), a non-selective herbicide, on the brain of infantile rats was studied. Because of the structural analogy between GLA and glutamate, GLA-exposed rats were examined for the wet-dog shakes response to kainic acid. Seven-day-old female rats were injected subcutaneously with a dose 1, 2 or 5 mg/kg GLA daily …
Ameliorating effect of olive oil on fertility of male rats fed on genetically modified soya bean
Abstract: Background. Genetically modified soya bean (GMSB) is a commercialized food. It has been shown to have adverse effects on fertility in animal trials. Extra virgin olive oil (EVOO) has many beneficial effects including anti-oxidant properties. The aim of this study is to elucidate if addition of EVOO ameliorates the adverse effects on reproductive organs …
