Journal or Publishing Institution: Young Scientist
Study: https://molodyivchenyi.ua/index.php/journal/article/view/3809
Author(s): Chorna, I.V., Dronyk, G.V. and Rogozinsky, M.S.
Article Type: Peer Reviewed Study
Abstract:
The article summarizes the literature data on the implementation of biochemical assessment of the safety of the use of genetically modified organisms, classification and characterization of the antioxidant protection system of the animal body. An important role in assessing the safety of the use of genetically modified products is played by the antioxidant protection system. The basis of the antioxidant protection system is the glutathione system, which consists of glutathione and enzymes that catalyze reduction and oxidation reactions. The antioxidant system is conventionally divided into enzymatic and non-enzymatic. The enzymatic link of the antioxidant protection system includes: catalase, peroxidase, superoxide dismutase, glutathione peroxidase, glutathione reductase, glutathione transferase and other enzymes. The non-enzymatic link includes fat-soluble (vit. A, E and K) and water-soluble vitamins (vit. C and PP), glutathione, ubiquinone, biogenic amines, carotenoids and sterols. The enzymatic link of the antioxidant system is considered in more detail. The activity of antioxidant enzymes is very well regulated and depends on the age of the animal, physiological state, pH of the environment, the rate of synthesis of antioxidant enzymes, the presence of coenzymes, inhibitors and activators, and other factors can also affect the activity of enzymes (radiation exposure, tumor growth, exposure to toxic substances and other pathological processes), therefore, the study of the antioxidant defense system can serve as one of the main criteria for assessing the safety of the use of genetically modified plants.
Keywords: genetically modified organisms, safety assessment, antioxidant defense system, antioxidants, glutathione, glutathione peroxidase, glutathione reductase, glutathione transferase, catalase, superoxide dismutase, rat, rats, rodent, rodents, GM soy, GMO Soya, soybean, soybeans
Citation:
Chorna, I.V., Dronyk, G.V. and Rogozinsky, M.S., 2018. Biological significance of antioxidant defense system indicators in assessing the safety of genetically modified organisms. Young Scientist, (10 (62)), pp.461-469.
Category:
- Health effects
Record ID: 2785
