Jarida ko Cibiyar Bugawa: Muhalli na Duniya
Nazarin: https://www.sciencedirect.com/science/article/pii/S0160412021006632
Author (s): Liu, JB, Li, ZF, Lu, L., Wang, ZY da Wang, L.
Nau'in Rubuta: Nazarin Tsara Nazari
Abstract:
Blood-testis barrier (BTB) yana haifar da gata mai gata wanda ba makawa ga maniyyi. Glyphosate (GLY), maganin ciyawa da aka fi amfani da shi a duk duniya, an ruwaito yana rage ingancin maniyyi. Duk da haka, ko da kuma yadda GLY ke lalata BTB don rinjayar ingancin maniyyi ya kasance da za a bayyana. A nan, an tsara wannan binciken don bincika tasirin GLY akan BTB a vivo da kuma a vitro gwaje-gwaje. Sakamakon ya nuna cewa berayen da aka fallasa ga GLY na tsawon watanni 4 sun nuna raguwar ingancin maniyyi da yawa, tare da rushewar amincin BTB da damuwa na oxidative na testicular. Bugu da ƙari, nau'in oxygen mai amsawa GLY (ROS) ya ba da gudummawa ga raguwar sunadaran da ke da alaƙa da BTB a cikin ƙwayoyin Sertoli na farko (SCs). Abin ban sha'awa, mun gano alamar haɓakar ƙwayar cuta mai alaƙa da damuwa NOX1 a cikin GLY- fallasa gwaji bisa binciken kwafi. NOX1 ƙwanƙwasawa ya toshe damuwa mai oxidative mai haifar da GLY, haka kuma ya hana raguwar furotin da ke da alaƙa da BTB a cikin SCs. Bugu da ƙari kuma, mai karɓar isrogen (ER) -a an inganta shi sosai a vivo da kuma a vitro samfura. Mai hana ER-α ya rage matakan magana na ER-a da NOX1. Mechanistically, GLY yayi hulɗa kai tsaye tare da ER-α a wurin Pro39 da Lys401 don haɓaka kunnawar ER-α, wanda ya haɓaka magana ta NOX1 don haifar da tarin ROS. Gabaɗaya, waɗannan sakamakon sun nuna cewa bayyanar GLY na dogon lokaci yana da illa ga amincin BTB, wanda ke rushe spermatogenesis ta hanyar kunna axis ER-α / NOX1. Wannan binciken yana ba da kyakkyawar fahimta game da haɗarin bayyanar GLY na dogon lokaci ga haihuwa na namiji.
keywords: Glyphosate, shingen gwajin jini, damuwa na Oxidative, NOX1, mai karɓar Estrogen-α
Kira:
Liu, JB, Li, ZF, Lu, L., Wang, ZY da Wang, L., 2022. Glyphosate yana lalata shingen gwajin jini ta hanyar NOX1 mai haifar da damuwa na oxidative a cikin berayen: Bayyanar lokaci mai tsawo azaman haɗarin haɗari ga haifuwar namiji. lafiya. Muhalli na Duniya, 159, p.107038.
