Search Results for: Gastrointestinal

Abstract: Autism is a neurodevelopmental disorder for which a number of genetic, environmental, and nutritional causes have been proposed. Glyphosate is used widely as a crop desiccant and as an herbicide in fields of genetically modified foods that are glyphosate resistant. Several researchers have proposed that it may be a cause of autism, based on …

Abstract: The persistence of plant-derived recombinant DNA in sheep and pigs fed genetically modified (Roundup Ready) canola was assessed by PCR and Southern hybridization analysis of DNA extracted from digesta, gastrointestinal (GI) tract tissues, and visceral organs. Sheep (n = 11) and pigs (n = 36) were fed to slaughter on diets containing 6.5 or 15% …

Abstract: Glyphosate is the isopropyl amine salt of N-(Phosphonomethyl)-glycine, a broad-spectrum nonselective herbicide, which has been extensively used to control annual and perennial weeds in agricultural, forest and aquatic systems. The ultrastructural changes in different regions of alimentary canal and gill were observed by Scanning Electron Microscopic study on a non-target aquatic teleostea fish, Channa …

Abstract: Food-ingested foreign DNA is not completely degraded in the gastrointestinal tract of mice. Phage M13mp18 DNA as a test molecule devoid of homology to mouse DNA was pipette-fed to or added to the food supply of mice. The fate of this foreign DNA in the animals was followed by several methods. In 84 animals, …

Abstract: Knowing early nutritional status have been shown to be an important factor in determining the activity level of rats later in life, we studied offspring of dams which had received 50, 70 or 700 mg/kg of 2,4-Dichlorophenoxyacetic acid (2,4-D) during nursing. Neonatal tissues and the stomach content (milk) were examined up to 16 post …

Abstract: Our bloodstream is considered to be an environment well separated from the outside world and the digestive tract. According to the standard paradigm large macromolecules consumed with food cannot pass directly to the circulatory system. During digestion proteins and DNA are thought to be degraded into small constituents, amino acids and nucleic acids, respectively, …

Abstract: Glyphosate, the active ingredient in Roundup®, is the most popular herbicide used worldwide. The industry asserts it is minimally toxic to humans, but here we argue otherwise. Residues are found in the main foods of the Western diet, comprised primarily of sugar, corn, soy and wheat. Glyphosate’s inhibition of cytochrome P450 (CYP) enzymes is …

Abstract: The case fatality from acute poisoning with glyphosate-containing herbicides is approximately 7.7% from the available studies but these have major limitations. Large prospective studies of patients with self-poisoning from known formulations who present to primary or secondary hospitals are needed to better describe the outcome from acute poisoning with glyphosate-containing herbicides. Furthermore, the clinical …

Abstract: The effect of the digestion process in the gastro-intestinal tract (GIT) of animal models on the fate and integrity of plant DNA has been widely evaluated since DNA availability and integrity is a key factor for hypothetical horizontal gene transfer of recombinant DNA from GM crop-derived feeds to animal and human gut microflora. In this study, plant DNA sequences …

Abstract: For the safety evaluation of genetically engineered crops the potential allergenicity of the newly introduced protein(s) has become an important issue. There is, however, no universal and reliable test system for the evaluation of the allergenic potency of food products. The best known allergy assessment proposal is the careful stepwise process using the IFBC/ILSI …

Abstract: Genetically modified (GM) crops have been commercially available for human and animal consumption since the 1990s. The safety evaluations are based on the concept of substantial equivalence, which assumes that the toxicity of a product can be investigated by assessing the toxicity of individual components of the product and not the product as a …

Abstract: The objective of this study was to investigate the uptake of dietary DNA into blood, kidney, and liver of salmon, and to determine the DNA fragment size if dietary DNA was detected. Salmon in groups of five fish were force-fed a feed containing a high copy number of three polymerase chain reaction (PCR) amplified …

Abstract: The 35S cauliflower mosaic virus (CaMV) promoter is commonly used to drive transgene expression in the genetically engineered (GE) crop plants that have been commercialized so far. Whether, and how far, the 35S promoter might be active in mammalian cells has been scientifically unsettled and controversial. Very recently it was established that the 35S …

Text: Is ‘rare’ rare enough to be acceptable? Increasing microbial resistance to antibiotics is a wellestablished threat to human health and so there is a need for a global strategy to combat this increase (1). In the past, attention has mostly been paid to create a holistic strategy for usage of these drugs in prophylactic …

Abstract: Background Glyphosate-based herbicides (GBHs) are broad-spectrum herbicides that act on the shikimate pathway in bacteria, fungi, and plants. The possible effects of GBHs on human health are the subject of an intense public debate for both its potential carcinogenic and non-carcinogenic effects, including its effects on microbiome. The present pilot study examines whether exposure …

Abstract: The safety assessment of genetically modified (GM) plants and their derived food and feed is nowadays a matter of lively debate. Any nutritional consequence of GM food consumption needs to be considered, both in terms of possible changes in the levels of nutrients in the food itself, and in terms of direct or indirect, …

Abstract: During the last 10-15 years, an increase of Clostridium botulinum associated diseases in cattle has been observed in Germany. The reason for this development is currently unknown. The normal intestinal microflora is a critical factor in preventing intestinal colonisation by C. botulinum as shown in the mouse model of infant botulism. Numerous bacteria in …

Abstract: Genetically modified (GM) plants expressing insecticidal traits offer a new strategy for crop protection. GM-corn contains Bacillus thuringiensis (Bt) genes producing delta endotoxins in the whole plant. Diet can influence the characteristics of the gastrointestinal tract altering its function and structure. The aim of this study was to evaluate the effect of GM-corn on …

Abstract: The objective of this study was to evaluate whether standard fish meal diets prepared with increasing levels of genetically modified (GM; 150 and 300 g kg−1) maize (event MON810®) as a starch source, showed any nutritional or physiological adverse effects on Atlantic salmon, Salmo salar L. postsmolt. The diets with low or high inclusions of GM …

Abstract: An association between malignant lymphoma (both Hodgkin’s disease (HD) and non-Hodgkin lymphoma) and exposure to organic solvents, phenoxy acids, or chlorophenols was previously reported. A reanalysis of this investigation regarding the cases with HD and exposure to various chemicals was performed and resulted in comparable findings to the whole group of malignant lymphoma. There …

Text: Introduction. With the advent of introducing genetic engineering in agricultural sciences and food production, food safety has become a major issue.[1] The genetic content of the organisms is altered using these techniques that result into genetically engineered organism (plants/animals) also known as genetically modified organisms. Human beings mainly depend upon plants for their food …

Abstract: Because certain hereditary diseases show autistic behavior, and autism often runs in families, researchers seek genes underlying the pathophysiology of autism, thus core behaviors. Other researchers argue environmental factors are decisive, citing compelling evidence of an autism epidemic in the United States beginning about 1980. Recognition that environmental factors influence gene expression led to …

To the editor: Your May 29 editorial1 about the health risks of genetically modified (GM) food was apposite and addresses some of the important medical issues vigorously. It beggars belief that “badly designed, poorly carried out, inaccurately interpreted experiments” could have perpetuated such profound public debate for almost a year. Regrettably, among the correspondents who …

Text: Widespread distribution of genetically modified organisms (GMO) causes great biological risks for human and the Environment. Three kind of biological risks are described usually: ecological, nutrition and agrotechnical. The term genetically modified organisms (GMOs) refers to plants, microbes and animals with genes transferred from other species in order to produce certain novel characteristics (for …

Text: Yu and Rohan (1) are to be commended for their comprehensive literature review of the mitogenic and apoptotic actions of insulin-like growth factor (IGF)-I and of the epidemiologic evidence incriminating elevated levels of circulating IGF with excess risks of breast, colorectal, prostate, and other cancers. This evidence is supported by the excess risks of …