Search Results for: Cancer
Human health risks of the use of glyphosate and glyphosate-based herbicides: Review
Abstract: Glyphosate used in genetically modified organism soybean and corn production. Glyphosate can lead health problems in individuals exposed the chemical occupationally and environmentally as well as air, water and food. Glyphosate (N-phosphonomethyl glycine) is a broadspectrum weedkillers (herbicide) widely used all over the world. Glyphosate is inhibited 5-enolpurivilshikimic acid-3-phosphate synthase in the shikimate pathway …
Glyphosate, pathways to modern diseases II: Celiac sprue and gluten intolerance
Abstract: Celiac disease, and, more generally, gluten intolerance, is a growing problem worldwide, but especially in North America and Europe, where an estimated 5% of the population now suffers from it. Symptoms include nausea, diarrhea, skin rashes, macrocytic anemia and depression. It is a multifactorial disease associated with numerous nutritional deficiencies as well as reproductive …
Glyphosate’s suppression of cytochrome P450 enzymes and amino acid biosynthesis by the gut microbiome: pathways to modern diseases
Abstract: Glyphosate, the active ingredient in Roundup®, is the most popular herbicide used worldwide. The industry asserts it is minimally toxic to humans, but here we argue otherwise. Residues are found in the main foods of the Western diet, comprised primarily of sugar, corn, soy and wheat. Glyphosate’s inhibition of cytochrome P450 (CYP) enzymes is …
América Latina y Monsanto (Fundamentos y Debate)
Abstract: Latin America is a key area for the expansion of genetically modified agriculture. Monsanto’s herbicide, Roundup, with glyphosate as its active ingredient, is heavily sprayed as an essential part of the GM model. Since half of Monsanto’s revenue comes from its Roundup products, the company has a significant investment in promoting glyphosate’s safety, as …
Malignant lymphomas and occupational exposures
Abstract: The effects of potential risk factors for Hodgkin’s disease (HD) and for non-Hodgkin lymphomas (NHL) were evaluated in a case-referent study encompassing 54 cases of HD, 106 cases of NHL, and 275 referents, all alive. Exposure information was obtained by questionnaires posted to the subjects. Crude rate ratios were increased for various occupational exposures …
Genetically engineered “golden” rice unlikely to overcome vitamin A deficiency/Response
To the editors: The suggestion that “golden” rice, bioengineered to contain Beta-carotene (1), could have a “real impact on the health of children living in Southeast Asia” (2) deserves critical scrutiny from nutrition professionals. This rice, although not yet available commercially, has become the “poster child” of the food biotechnology industry’s extensive public relations campaign …
Some occupational exposures as risk factors for malignant lymphomas
Abstract: Malignant lymphomas (Hodgkin disease [HD] and non-Hodgkin lymphoma [NHL]) have been subject to several epidemiologic studies and found to be associated with various environmental exposures, especially solvents, wood, and phenoxy herbicides. Various determinants for HD and NHL were evaluated in a case-referent study encompassing 31 cases of HD, 93 cases of NHL, and 204 …
A case-control study of non-Hodgkin lymphoma and exposure to pesticides
Abstract: BACKGROUND. The incidence of non-Hodgkin lymphoma (NHL) has increased in most Western countries during the last few decades. Immunodefective conditions are established risk factors. In 1981, the authors reported an increased risk for NHL following exposure to certain pesticides. The current study was designed to further elucidate the importance of phenoxyacetic acids and other …
Pesticide assessment: Protecting public health on the home turf
Abstract: Pesticide regulation is examined in the context of Health Canada’s Pest Management Regulatory Agency’s assessment of the chlorophenoxy herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) for turf. 2,4-D is the most common herbicide used to kill weeds in grass. The medical literature does not uniformly indicate harms from herbicides. However, the balance of epidemiological research suggests that 2,4-D can …
Clastogenic effects of glyphosate in bone marrow cells of swiss albino mice
Abstract: Glyphosate (N-(phosphonomethyl) glycine, P), a herbicide, used to control unwanted annual and perennial plants all over the world. Nevertheless, occupational and environmental exposure to pesticides can pose a threat to nontarget species including human beings. Therefore, in the present study, genotoxic effects of the herbicide glyphosate were analyzed by measuring chromosomal aberrations (CAs) and …
Pesticides and human chronic diseases: Evidences, mechanisms, and perspectives
Abstract: Along with the wide use of pesticides in the world, the concerns over their health impacts are rapidly growing. There is a huge body of evidence on the relation between exposure to pesticides and elevated rate of chronic diseases such as different types of cancers, diabetes, neurodegenerative disorders like Parkinson, Alzheimer, and amyotrophic lateral …
Pesticides and non-Hodgkin’s lymphoma
Abstract: The incidence of non-Hodgkin’s lymphoma (NHL) has increased over 50% in the last 15 years. This paper reviews the possible role of pesticides in this increase. While small increases in risk of NHL among farmers have been observed in general occupational surveys, recent studies focusing on specific pesticides have observed much larger risks. Frequent …
How sustainable agriculture can address the environmental and human health harms of industrial agriculture
Abstract: The industrial agriculture system consumes fossil fuel, water, and topsoil at unsustainable rates. It contributes to numerous forms of environmental degradation, including air and water pollution, soil depletion, diminishing biodiversity, and fish die-offs. Meat production contributes disproportionately to these problems, in part because feeding grain to livestock to produce meat–instead of feeding it directly …
Exposure to phenoxyacetic acids, chlorophenols, or organic solvents in relation to histopathology, stage, and anatomical localization of non-Hodgkin’s lymphoma
Abstract: Results on 105 cases with histopathologically confirmed non-Hodgkin’s lymphoma (NHL) and 335 controls from a previously published case-control study on malignant lymphoma are presented together with some extended analyses. No occupation was a risk factor for NHL. Exposure to phenoxyacetic acids yielded, in the univariate analysis, an odds ratio of 5.5 with a 95% …
Soft-tissue sarcomas and exposure to chemical substances: A case-referent study
Abstract: In 1977 several patients were seen with soft-tissue sarcomas and previous exposure to phenoxy acids. This clinical observation resulted in a cases-referent (case-control) study being undertaken which showed that exposure to phenoxy acids or chlorophenols, which are chemically related, gave a roughly six-fold increase in the risk for this type of tumour. A further …
Epidemiological study of socioeconomic factors and clinical findings in Hodgkin’s disease, and reanalysis of previous data regarding chemical exposure
Abstract: An association between malignant lymphoma (both Hodgkin’s disease (HD) and non-Hodgkin lymphoma) and exposure to organic solvents, phenoxy acids, or chlorophenols was previously reported. A reanalysis of this investigation regarding the cases with HD and exposure to various chemicals was performed and resulted in comparable findings to the whole group of malignant lymphoma. There …
Malignant lymphoma and exposure to chemicals, especially organic solvents, chlorophenols and phenoxy acids: A case-control study
Abstract: A number of men with malignant lymphoma of the histiocytic type and previous exposure to phenoxy acids or chlorophenols were observed and reported in 1979. A matched case-control study has therefore been performed with cases of malignant lymphoma (Hodgkin’s disease and non-Hodgkin lymphoma). This study included 169 cases and 338 controls. The results indicate …
Case-control study: Soft-tissue sarcomas and exposure to phenoxyacetic acids or chlorophenols
Abstract: In 1977 a number of patients with soft-tissue sarcomas and previous exposure to phenoxyacetic acids were described. Following from these observations a matched case-control study was made. Exposure to chlorophenols was also included in this study. The results showed that exposure to phenoxyacetic acids or chlorophenols gave an approximately 6-fold increase in the risk …
Pesticide exposure as risk factor for non-Hodgkin lymphoma including histopathological subgroup analysis
Abstract: We report a population based case-control study of exposure to pesticides as risk factor for non-Hodgkin lymphoma (NHL). Male and female subjects aged 18-74 years living in Sweden were included during December 1, 1999, to April 30, 2002. Controls were selected from the national population registry. Exposure to different agents was assessed by questionnaire. …
Case-Control Study of Canine Malignant Lymphoma: Positive Association With Dog Owner’s Use of 2, 4-Dichlorophenoxyacetic Acid Herbicides
Abstract: A hospital-based case-control study of companion dogs examined the risk of developing canine malignant lymphoma associated with the use of chemicals in and about the home. Information from a self-administered owner questionnaire and/or a telephone interview of about 491 cases, 466 nontumor controls, and 479 tumor controls indicated that owners in households with dogs …
Potentially dangerous risks of genetically modified food products
Abstract: Introduction. The prolonged and uncontrolled use of genetically modified foods represents the adverse potential effects and threats to human health. Discussion. Discovered the toxic and allergenic influence of number of transgenic proteins on the human organism. The inhibitors of alpha amylases are strong allergens which form complexes with the ferments of the salivary glands …
Glyphosate‐based pesticides affect cell cycle regulation
Abstract: Cell-cycle dysregulation is a hallmark of tumor cells and human cancers. Failure in the cell-cycle checkpoints leads to genomic instability and subsequent development of cancers from the initial affected cell. A worldwide used product Roundup 3plus, based on glyphosate as the active herbicide, was suggested to be of human health concern since it induced …