Search Results for: Teratogenic
Glyphosate-based herbicides produce teratogenic effects on vertebrates by impairing retinoic acid signaling
Abstract: The broad spectrum herbicide glyphosate is widely used in agriculture worldwide. There has been ongoing controversy regarding the possible adverse effects of glyphosate on the environment and on human health. Reports of neural defects and craniofacial malformations from regions where glyphosate-based herbicides (GBH) are used led us to undertake an embryological approach to explore …
Teratogenicity: A mechanism based short review on common teratogenic agents
Abstract: Teratogenicity or reproductive and developmental toxicity has increasingly been recognized as a most important part of overall toxicology. Each compound has its own unique toxicological profile and mechanism of teratogenicity. The present view-point was to explore and review the teratogenic mechanism and common teratogenic effects of teratogenic compounds, biological agents and physical agents. Every …
The teratogenic potential of the herbicide glyphosate-Roundup in Wistar rats
Abstract: The aim of this study was to assess the teratogenicity of the herbicide glyphosate-Roundup (as commercialized in Brazil) to Wistar rats. Dams were treated orally with water or 500, 750 or 1000 mg/kg glyphosate from day 6 to 15 of pregnancy. Cesarean sections were performed on day 21 of pregnancy, and number of corpora …
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Search the primary studies database using one of the pre-defined keyword searches below. # 2,4-Dichlorophenoxyacetic acid (2,4-D) 35S A Acetylcholinesterase Aegilops cylindrica Aflatoxin Africa African Catfish (Clarias Gariepinus) African clawed frog (Xenopus laevis) Agrobacterium Agroecology Agrostis Agrostis stolonifera Alfalfa (Medicago sativa) Allergy Alpaida Veniliae Amaranthus palmeri Amaranthus tuberculatus Ambrosia artemisiifolia Ambystoma gracile Ambystoma laterale Ambystoma …
Pesticides used in South American GMO-based agriculture: A review of their effects on humans and animal models
Abstract: In South America, the incorporation of genetically modified organisms (GMO) engineered to be resistant to pesticides changed the agricultural model into one dependent on the massive use of agrochemicals. Different pesticides are used in response to the demands of the global consuming market to control weeds, herbivorous arthropods, and crop diseases. Here, we review …
Inhibition of intercellular communication in cultures of Chinese hamster V79 cells by 2,4-dichlorophenoxyacetic acid and 2,4,5-trichlorophenoxyacetic acid
Abstract: Using the Chinese hamster V79 in vitro cell system designed to measure intercellular communication, 2,4-dichlorophenoxyacetic acid (2,4-D), 2,4,5-trichlorophenoxyacetic acid (2,4,5-T), and several mixtures of these compounds were tested for their ability to inhibit this biological process. The ability of these chemicals to inhibit colony-forming ability of these cells was tested prior to the studies …
Glyphosate induces neurotoxicity in zebrafish
Abstract: Glyphosate based herbicides (GBH) like Roundup® are used extensively in agriculture as well as in urban and rural settings as a broad spectrum herbicide. Its mechanism of action was thought to be specific only to plants and thus considered safe and non-toxic. However, mounting evidence suggests that GBHs may not be as safe as …
Carcinogenicity and toxicity of 2,4-dichlorophenoxy-acetic acid
Abstract: 2,4-Dichlorophenoxyacetic acid (2,4-D) is carcinogenic in male and female rats and probably also in mice. Male and female rats ingesting 2,4-D developed increased incidences of malignant neoplasms. Lymphosarcomas were increased in rats of both sexes, and neoplasms of the mammary gland in female rats. Male rats also had carcinomas of the endocrine organs. 2,4-D …
Acute and sublethal toxicity and indirect effects of glyphosate and its formulations on amphibians – A review
Abstract: The world wide and continuously increasing contamination of aquatic and terrestrial ecosystems with pesticides and other agrochemicals is considered as a main factor causing global amphibian declines. Glyphosate, the most commonly used nonselective systemic herbicide, is sold under a variety of commercial names (e. g. Roundup® and Vision®), and is promoted by the introduction …
Potential toxic effects of glyphosate and its commercial formulations below regulatory limits
Abstract: Glyphosate-based herbicides (GlyBH), including Roundup, are the most widely used pesticides worldwide. Their uses have increased exponentially since their introduction on the market. Residue levels in food or water, as well as human exposures, are escalating. We have reviewed the toxic effects of GlyBH measured below regulatory limits by evaluating the published literature and …
Pesticides used in South American GMO-based agriculture: A review of their effects on humans and animal models
Abstract: In South America, the incorporation of genetically modified organisms (GMO) engineered to be resistant to pesticides changed the agricultural model into one dependent on the massive use of agrochemicals. Different pesticides are used in response to the demands of the global consuming market to control weeds, herbivorous arthropods, and crop diseases. Here, we review …
Developmental effects of glufosinate ammonium on mammalian embryos in vitro
Abstract: Glufosinate ammonium, which is a component of the herbicide BASTA, is a phosphinic analog of glutamic acid. Its activity is related to the inhibition of glutamine synthetase. Previous studies demonstrated that glufosinate has no teratogenic potential in rats and rabbits in vivo. In the present study, we determined whether glufosinate could affect embryonic development …
Environmental health problems of glyphosate applications
Abstract: Glyphosate-based herbicides are leading products of the current pesticide market, and this trend has further strengthened outside Europe with the spread of glyphosate-tolerant GM crops. Glyphosate forms complexes with metal ions (Al, Fe, Mn, Zn) in the soil, but precipitation washes it into deeper soil layers. Its primary metabolite, AMPA, is more mobile than …
