Joornaalka ama Hay'adda Daabacaadda: Cilmi-baarista Deegaanka
Daraasada: https://www.sciencedirect.com/science/article/pii/S0013935122006430
Qoraha (yada) Makris, KC, Efthymiou, N., Konstantinou, C., Anastasi, E., Schoeters, G., Kolossa-Gehring, M. iyo Katsonouri, A.
Nooca Maqaalka: Daraasaadka Dib-u-eegis ee asaaga
aan la taaban karin,
Background
Soo-gaadhista sunta cayayaanka ee kala duwan, sida pyrethroids iyo chlorpyrifos, ayaa hore loola xidhiidhiyay saamaynta xun ee caafimaadka carruurta. Caddayn saynis ah oo ku saabsan sunta aadanaha ee glyphosate (GLY) iyo dheef-shiid kiimikaadkeeda aasaasiga ah, aminomethylphosphonic acid (AMPA) ayaa xaddidan, gaar ahaan carruurta. Daraasadani waxay ujeedadeedu tahay i) inay qiimeeyaan soo-gaadhista sunta cayayaanka ee la bartay ee lagu cabbiray carruurta Qubrus, iyo ii) go'aaminta xidhiidhka ka dhexeeya sunta cayayaanka kaadida iyo kuwa biomarkers ee DNA iyo waxyeelada oxidative.
Dariiqooyinka
Daraasad caafimaad oo carruurta ah ayaa lagu dhisay Qubrus (daraasaadka ORGANIKO) iyadoo la waafajiyay habka iyo aaladaha loo adeegsado Hindisaha Biomonitoring Initiative ee Yurub (HBM4EU). Urinary GLY iyo AMPA, pyrethroid metabolites iyo chlorpyrifos metabolite TCPy ayaa lagu qiyaasay 177 carruur ah oo ay da'doodu u dhaxayso 10-11 sano, iyadoo la adeegsanayo spectrometry mass. murqo- waxaa lagu qiimeeyay 8-iso-prostaglandin F2a (8-iso-PGF2α) oo ah calaamad muujinaysa dhaawaca dufanka iyo 8-hydroxy-2'-deoxyguanosine (8-OHdG) oo ah calaamadda dhaawaca oksaydhka DNA, labadaba lagu qiyaasay immunoassays. Su'aalo-waraysiyo ku saabsan sifooyinka tirakoobka, isticmaalka sunta cayayaanka, iyo caadooyinka cuntada ayaa waalidku buuxiyey. Moodooyinka dib-u-celinta ultivariable waxay baari jireen ururada ka dhexeeya sunta cayayaanka iyo biomarkers saamaynta iyadoo la adeegsanayo laba hagaajinta creatinine (cr1: ku darista sida covariate iyo cr2: biomarkers of soo-gaadhista iyo saamaynta ayaa la hagaajiyay creatinine).
Natiijooyinka
Heerka waxbarashada waalidku wuxuu ahaa saadaaliye muhiim ah oo ku saabsan pyrethroids kaadi mareenka laakiin maaha GLY/AMPA. Dhexdhexaadka [kala duwanaanshaha, IQR] ee qiimayaasha GLY iyo AMPA waxay ahaayeen 0.19). Ururada la midka ah ee muhiimka ah ee leh 0.18-OHdG ayaa lagu muujiyay metabolite-ka pyrethroid (0.10-PBA) iyo chlorpyrifos metabolite (TCPy). Ma jiraan wax ururo ah oo lagu arkay inta u dhaxaysa sunta cayayaanka aan soo sheegnay iyo 0.29-iso-PGF0.45α (p> 8).
Gabagabada
Tani waa xog-ururinta caafimaadka carruurta ee ugu horraysa oo muujinaysa xidhiidhka ka dhexeeya AMPA iyo DNA-da waxyeelada oksijiinta, adduunka oo dhan. Xog dheeraad ah ayaa loo baahan yahay si loogu celceliyo isbeddellada lagu arkay carruurta kale ee adduunka oo dhan.
Keywords: Dabagalka bayooloji ee bini'aadamka, Sunta cayayaanka, Carruurta, Glyphosate, AMPA, stress Oxidative
Sharax:
Makris, KC, Efthymiou, N., Konstantinou, C., Anastasi, E., Schoeters, G., Kolossa-Gehring, M. iyo Katsonouri, A., 2022. Cadaadiska Oxidative ee glyphosate, AMPA iyo dheef-shiid kiimikaad ee pyrethroids iyo chlorpyrifos sunta cayayaanka ee carruurta dugsiyada hoose ee Qubrus. Cilmi-baarista Deegaanka, 212, p.113316.