Journal or Publishing Institution: International Journal of Biology, Pharmacy and Applied Sciences (IJBPAS)
Author(s): Owrang, I., Najafian, M., and Johari, H.
Article Type: Peer Reviewed Study
Record ID: 1872
Abstract: Roundup is Glyphosate brand, the family of Phosphonic acid (isopropyl amine salt) and is used for after the preparation is highly toxic and can be absorbed through the skin. It also stated that in ancient medicine, Ginger as an anti-inflammatory herb is introduced.
But so far hasn’t been made any study in association with the antioxidant effect of this
plant on destructive effects of Glyphosate on changes in sex hormones that the main
objective of the present study. 56 adult female Wistar rats were selected and divided into 7 groups of 8, Group C without receiving any medication. Group S that received saline solution. Group Z100 100mg/kg B.W zingiber, group Z400 400 mg / kg B.W zingiber , group G100 100mg/kg B.W glyphosate, group GZ100 100mg/kg B.W glyphosate with zingiber 100mg/kg B.W and group GZ400 100mg/kg B.W glyphosate with 400 mg / kg B.W zingiber intraperitoneally received. At the end of the 21 day period, the rats were bled from the hormonal changes of LH, FSH, estrogen and progesterone was measured. The results show that the concentration of the hormones LH, FSH, Estrogen and Progesterone in group S, Z100 is not a significant difference compared to control. The hormones in Z400 have significantly increased compared to controls (P <0.05). In G100, with the effect of poison damage of glyphosate on Pituitary-gonadal axis causes all hormones are reduced significantly. In GZ100 and GZ400 groups that received toxin glyphosate with zingiber, somewhat improved glyphosate toxin degradation. Glyphosate with the production of reactive oxygen species and alkylating properties causes decreasing the effects of sex hormones. Zingiber also with an anti-inflammatory and antioxidant properties in a dose dependent manner, reduce the damaging effects of glyphosate.
Keywords: Roundup, Glyphosate, Toxic, Ginger, Anti-Inflammatory, Antioxidant, Wistar Rats, Poison Damage, Sex Hormones
Citation: Owrang, I., Najafian, M., and Johari, H., 2013. Antioxidant effect of ginger on the pituitary-gonadal axis hormones recovered from the devastating effects of the herbicide glyphosate in female rats. International Journal of Biology, Pharmacy and Applied Sciences (IJBPAS), 2(8): 1606-1616.
