Journal or Publishing Institution: Natural Product Research
Study: http://www.ncbi.nlm.nih.gov/pubmed/22455986
Author(s): Marrelli, M., Tudisco, R., Mastellone, V. and Conforti, F.
Article Type: Peer Reviewed Study
Record ID: 1513
Abstract: Colon cancer is one of the major causes of cancer mortality worldwide. The analysed feeds, containing non-genetically modified (GM) soybean and Roundup Ready soybean, showed a different polyphenolic content and lipophilic composition. Non-GM soybean extract possessed twice the polyphenolic content of GM soybean and the highest number of sterols. Among them, γ-sitosterol was found to be the major constituent. Methanolic extract of non-GM soybean extract was more potent than GM soybean extract against colon carcinoma cell line LoVo using MTT assay, while the second one showed a slightly higher anti-inflammatory activity. The findings add to epidemiological evidence for the therapeutic effects of soy foods in colorectal carcinoma.
Keywords: Fatty Acids, Colorectal Carcinoma, NO Production, Phytosterols, Soybean; Animals, Cell Line, Colorectal Neoplasms, Gas Chromatography, Mass Spectrometry, Humans, Mice, Nitrogen Oxides, Phenols, Phytosterols, Plant Extracts, Genetically Modified Plants, Soybeans; Diet Therapy, Metabolism, Chemistry, Therapeutic Use; Glycine Max, Anti-Inflammatory Activity, Anticarcinogenic Activity, Foods, Mortality, Sterols, Therapeutics
Citation: Marrelli, M., Tudisco, R., Mastellone, V. and Conforti, F., 2013. A comparative study of phytochemical composition of genetically and non-genetically modified soybean (Glycine max L.) and evaluation of antitumor activity. Natural Product Research, 27(6), pp.574-578.
