Journal or Publishing Institution: Cancer Therapy
Author(s): Israël, M.
Article Type: Journal Publication
Record ID: 1117
Abstract: We recently proposed that deficient cellular interactions in endocrine pancreas were a primary cause for cancer. Normally, insulin secreting beta cells release in parallel GABA, for inhibiting neighboring alpha and delta cells, releasing glucagon and somatostatin respectively. A deficiency of GABA release, will lead to a hybrid anaboliccatabolic metabolism, mediated by insulin and glucagon. They act via kinases and phosphatases, on enzymatic switches rewiring metabolism, this gives to mitotic cells a selective advantage, leading them to cancer. The pancreatic GABA starter hypothesis for cancer seems verified, on human populations consuming regularly palm tree betel nuts that contain classical GABA inhibitors; epidemiological studies showed an elevated cancer risk. Since vitamin B6 is the cofactor of glutamatedecarboxylase, GABA synthesis should decrease in processes deactivating vitamin B6, and increase cancer risk. Gyromitrin a hydrazine found in a mushroom (Gyromitra esculenta) forms vitamin B6-hydrazones de-activating the vitamin; gyrometrin was clearly carcinogenic for rodents fed with uncooked gyromitra. Pathologies deactivating vitamin B6 include Pellagra, a niacin deficiency due to maize diets. In this case, amines-vitamin B6 adducts would increase cancer risk as recently suspected. Another adduct of vitamin B6, is a B6-pyrrole identified in Prolinemia. Thus, pyrroles formed by the catabolism of pyrrolizidines alkaloids, found in boraginaceae and other plant families, will de-activate vitamin B6, explaining the carcinogenicity of pyrrolizidines. In addition, vitamin B6 supplementation seems to prevent cancer. A chronic GABA A receptor inhibition by pesticides was also carcinogenic. A pancreatic GABA deficiency in endocrine pancreas might then be a starter for cancer.
Keywords: alpha cells, beta cells, betel nuts, Cancer cause, delta cells, GAD, glucagon, guvacoline, gyromitrin, IGF, insulin, maize, nipecotic, nutrition-cancer, pancreas, pellagra, PP2A, pyrroles, pyrrolizidine, roundup, somatostatin, Vitamin B6, Zinc (Zn2+)
Citation: Israël, M., 2011. A primary cause of Cancer: GABA deficiency in endocrine pancreas. Cancer Therapy, 8.
