Journal or Publishing Institution: Aquaculture America
Study: https://web.archive.org/web/20180726162914/https://www.was.org/meetings/ShowAbstract.aspx?Id=35068
Author(s): Gómez-Ramirez, E., Borbón, J.F., González, J.F., Mocha, P.R.E., Chinnaiah, A., Subramanian, P., Beltran, L.G., Esquinas, P., García, E.L., Sierra, G.P., Giraldo, H.H., Duarte, W.R., Oanh, D.T.H., Phu, T.Q., Alcivar, M., Alejandro, D., and Alcivar-Warren, A.
Article Type: Report
Record ID: 810
Abstract: We present the long-term goals and research activities by collaborators of the ‘fishENCODE’ project, part of the global “ONE HEALTH Epigenomics Educational Initiative” (1). The goals of fishENCODE are to study the intergenerational epigenetic changes and adverse health effects to fish caused by endocrine disrupting chemicals (EDCs) such as the metal cadmium (Cd) and the herbicide Glyphosate. In tilapia Oreochromis mossambicus, Cd is an EDC at 150 parts per trillion, ppt (2). The gathered data on length-weight relation, gonado-somatic index, hepato-somatic index, vitellogenins, egg numbers and reproductive hormones such as gonadotropins (GtH-I & GtH-II) and gonadal hormones such as progesterone, testosterone and estradiol levels all indicated that Cd is an endocrine disruptor in tilapia (2). Though there is evidence for endocrine disruption of Atrazine and Glyphosate to O. mossambicus at parts per billion (ppb) concentrations (3), no studies that take into account the interactions of very low-levels of Glyphosate with fish hormones and receptors have been published following new scientific criteria for EDCs (4). Glyphosate is used in GMO-based crops such as soybeans used in aquafeeds. It is also a chelator and an antibiotic, and there are concerns about antibiotic resistance and new zoonotic diseases (1). We summarize here the results from an in-depth review of the scientific literature published in PubMed and Web of Science on adverse health effects to animals and human cells caused by EDCs. More research is needed that take into consideration the interaction of low (ppt) and high (up to 15 ppm found in GM soybeans) concentrations of Glyphosate with the fish genome and epigenome.
Citation: Gómez-Ramirez, E., Borbón, J.F., González, J.F., Mocha, P.R.E., Chinnaiah, A., Subramanian, P., Beltran, L.G., Esquinas, P., García, E.L., Sierra, G.P., Giraldo, H.H., Duarte, W.R., Oanh, D.T.H., Phu, T.Q., Alcivar, M., Alejandro, D., and Alcivar-Warren, A., 2015. Adverse health effects to fish caused by endocrine disrupting chemicals (edcs) – literature review and preliminary results on patterns of neuronal activation in the olfactory bulbs of white cachama piaractus brachypomus and hormonal changes in tilapia oreochromis sp. caused by exposures to commercial presentations of glyphosate. Aquaculture America Meeting.
