Journal or Publishing Institution: Proceedings Of the Japan Academy, Series B-Physical and Biological Sciences
Study: https://www.jstage.jst.go.jp/article/pjab1977/72/1/72_1_7/_pdf
Author(s): Fujii, T., Ohata, T. and Horinaka, M.
Article Type: Peer Reviewed Study
Record ID: 722
Abstract: Toxic effects of glufosinate ammonium (GLA), a non-selective herbicide, on the brain of infantile rats was studied. Because of the structural analogy between GLA and glutamate, GLA-exposed rats were examined for the wet-dog shakes response to kainic acid. Seven-day-old female rats were injected subcutaneously with a dose 1, 2 or 5 mg/kg GLA daily for 7 days. They were weaned at 3 weeks of age and tested for the response to 9 mg/kg kainic acid at 5 or 6 weeks of age. The frequency of wet-dog shakes induced by kainic acid showed a significant decrease in all GLA-exposed rats, though there was no significant difference among three dose groups. A significant decrease in the body weight gain was found in the 5 mg/kg GLA group. The results suggest that exposure to GLA, even in low doses, during infantile period in the rat induces alterations in the kainic acid receptor in the brain.
Keywords: Glufosinate ammonium, herbicide, kainic acid, infantile rats, brain, rodent
Citation: Fujii, T., Ohata, T. and Horinaka, M., 1996. Alternations in the response to kainic acid in rats exposed to glufosinate-ammonium, a herbicide, during infantile period. Proceedings Of the Japan Academy, Series B-Physical and Biological Sciences, Vol. 72, No. 1, pp. 7-10.
