Ameliorative effect of licorice extract against the detrimental effect of glyphosate-based pesticide: Toxicity and health.

Journal or Publishing Institution: Heliyon

Study: https://www.cell.com/heliyon/fulltext/S2405-8440(24)07654-0

Author(s): Elkattan, A.N., El-Saadany, S., Azzazy, M., Okda, T.M., Mamdouh, M., Ahmed, O., El-Far, A.H., ElKhayat, M., Albadrani, G.M., Al-Ghadi, M.Q. and Abdel-Daim, M.M.

Article Type: Peer Reviewed Study

Abstract:

This study sheds the light on the potential of licorice (Glycyrrhiza glabra) root aqueous extract as a cornerstone for mitigating and detoxifying the residues of the widely used agricultural Glyphosate-based pesticides (GBPs). This study examined the GBPs toxic effects on kidney, liver, thyroid functions, and apoptosis using 50 adult male albino rats. All rats were divided into 5 groups, with 10 each. Control: served as untreated rats. GBP: rats were treated with 1 mL glyphosate solution 24 % orally for three weeks. The glyphosate-treated rats were gavaged with licorice root aqueous extractsolution (100, 200, and 300 mg/mLdistilled water, respectively) daily for three weeks. Licorice root aqueous extract solution (300 mg/mL distilled water) yielded notable reductions in liver, kidney enzymes, albumin, and AFP levels within the serum. Immunological tests, including immunohistochemical evaluations of caspase-3 and TNF-α expressions revealed a dose-dependent attenuation of apoptosis and inflammation with licorice intervention. This will provide a valuable perspective for agricultural practices future and paving the way for a more sustainable approach for using GBPs in animal agriculture industries.

Keywords: Glyphosate-based pesticide, Toxicity, Licorice (Glycyrrhiza glabra), Antioxidant, Apoptosis

Citation:

Elkattan, A.N., El-Saadany, S., Azzazy, M., Okda, T.M., Mamdouh, M., Ahmed, O., El-Far, A.H., ElKhayat, M., Albadrani, G.M., Al-Ghadi, M.Q. and Abdel-Daim, M.M., 2024. Ameliorative effect of licorice extract against the detrimental effect of glyphosate-based pesticide: Toxicity and health. Heliyon, 10(10).

Category:

• Health effects

Record ID: 2790