Journal or Publishing Institution: Chemosphere
Study: https://www.sciencedirect.com/science/article/pii/S0045653517307269
Author(s): Sobjak, T.M., Romão, S., do Nascimento, C.Z., dos Santos, A.F.P., Vogel, L. and Guimarães, A.T.B.
Article Type: Peer Reviewed Study
Record ID: 2178
Abstract: The aim of this work was to investigate the effects of glyphosate on the antioxidant system, as well as the neurotoxic effects on the larvae of Rhamdia quelen. A completely randomized design was implemented with the eggs of silver catfish distributed in 48 containers with 300 mL of water, which were subdivided randomly into two groups: control and treated with 6.5 mg L of glyphosate. These groups were evaluated at four time points (12 h, 24 h, 48 h, and 72 h), each with six replications. The survival rate of eggs/larvae (%) was evaluated, and samples were collected for antioxidant system analysis (catalase – CAT, glutathione transferase – GST, glutathione reductase – GR, and lipoperoxidation – LPO), and neurotoxic evaluation (cholinesterase – ChE). Throughout the 72 h of experimentation, there was a higher survival rate among the animals treated with glyphosate. The highest value of integrated biomarkers response (IBR = 1.26) was at 12 h, presenting induction of the cholinesterase (ChE) enzyme and GR. At 24 h, the value of IBR was −2.56, with inhibition of ChE and induction of GR. At 48 h, the value was −0.76, with induction of LPO. The lowest value of IBR was at 72 h (−4.65), with induction of GST and inhibition of all other biomarkers. Finally, it was possible to detect an acute effect of glyphosate throughout the early development of R. quelen, with a decrease in the antioxidant system control and neurotoxic effects.
Keywords: Herbicide, Silver Catfish, Oxidative Stress, Neurotoxicity, Larviculture, Rhamdia quelen, cholinesterase, containers, early development, eggs, glutathione-disulfide reductase, glyphosate, larvae, neurotoxicity, survival rate, Animals, Antioxidants, Biomarkers, Catalase, Catfishes, Cholinesterases, Glutathione Reductase, Glutathione Transferase, Glycine, Larva, Neurotoxins, Oxidation-Reduction, Pesticides, Chemical Water Pollutants, Analysis, Pharmacology, Metabolism, Analogs & Derivatives, Drug Effects, Chemistry, Toxicity, Oxidative stress, Larviculture, Silver catfish, Herbicide
Citation: Sobjak, T.M., Romão, S., do Nascimento, C.Z., dos Santos, A.F.P., Vogel, L. and Guimarães, A.T.B., 2017. Assessment of the oxidative and neurotoxic effects of glyphosate pesticide on the larvae of Rhamdia quelen fish. Chemosphere, 182, pp.267-275.
