Journal or Publishing Institution: Journal of the National Cancer Institute
Study: http://jnci.oxfordjournals.org/content/83/17/1226
Author(s): Hayes, H.M., Tarone, R.E., Cantor, K.P., Jessen, C.R., McCurnin, D.M. and Richardson, R.C.
Article Type: Peer Reviewed Study
Record ID: 940
Abstract: A hospital-based case-control study of companion dogs examined the risk of developing canine malignant lymphoma associated with the use of chemicals in and about the home. Information from a self-administered owner questionnaire and/or a telephone interview of about 491 cases, 466 nontumor controls, and 479 tumor controls indicated that owners in households with dogs that developed malignant lymphoma applied 2, 4-dichlorophenoxyacetic acid (2, 4-D) herbicides to their lawn and/or employed commercial lawn care companies to treat their yard significantly more frequently than control owners (odds ratio = 1.3). In addition, the risk of canine malignant lymphoma rose to a twofold excess with four or more yearly owner applications of 2, 4-D. The findings in this study are consistent with occupational studies in humans, which have reported modest associations between agricultural exposure to 2, 4-D and increased risk of non-Hodgkin’s lymphoma, the histology and epidemiology of which are similar to those of canine malignant lymphoma. The present study suggests that human health implications of 2, 4-D exposure in the home environment should receive further investigation.
Keywords: 2, 4-D, 2, 4-dichlorophenoxyacetic acid, non-Hodgkin’s lymphoma, canine malignant lymphoma
Citation: Hayes, H.M., Tarone, R.E., Cantor, K.P., Jessen, C.R., McCurnin, D.M. and Richardson, R.C., 1991. Case-control study of canine malignant lymphoma: positive association with dog owner’s use of 2, 4-dichlorophenoxyacetic acid herbicides. JNCI: Journal of the National Cancer Institute, 83(17), pp.1226-1231.
