Journal or Publishing Institution: Bioresources and Nature Management
Study: https://elibrary.ru/item.asp?id=42361635
Author(s): Chorna, I.
Article Type: Peer Reviewed Study
Abstract:
The development and use of transgenic plants in animal husbandry and the food industry raise great concerns and debates in society. The effects of transgenic plants on humans and animals have not yet been sufficiently studied, which necessitates the study of the effects of genetically modified plants on metabolic processes in animals. The study of the effects of genetically modified plants on several generations of rats is important for assessing the safety of their use. Today, among all genetically modified plants, soybeans with the new trait “Roundup Ready” are most often used; such plants are resistant to the herbicide “Roundup” and are widely used throughout the world. That is why the study of both the separate and simultaneous effects of both of these factors on animals is very relevant today. The aim of the experimental studies was to study the effects of glyphosate-resistant genetically modified soybeans untreated and treated with the herbicide “Roundup” and the effect of the herbicide itself on the level of some nitrogen metabolism metabolites in the urine of three generations of rats. The object of the study was Wistar rats weighing 190-220 g at the age of 4 months. Five groups of animals were formed, with 16 rats in each (8 females and 8 males). Group I – intact animals (kept on a standard vivarium diet); Group II – animals in which 20-26% of the standard diet in terms of nutritional value was replaced with traditional soy; Group III – rats in which 20-26% of the standard diet was replaced with 26% of genetically modified soy treated with the herbicide “Roundup”; Group V – rats that consumed the herbicide together with drinking water at a dose of (0.003 μg / kg of animal weight). After 42 days, the rats were mated and the next generation was obtained. Another generation of rats was obtained in a similar way. The data of the experimental studies showed a decrease in the level of nitrogenous metabolites (creatinine and urea) and an increase in uric acid and protein levels in the urine of all three generations of rats in groups IV and V. When consuming traditional and transgenic soybeans not treated with herbicide, the level of nitrogen metabolism metabolites increases slightly. The detected changes indicate liver and kidney dysfunction, as well as protein metabolism disorders, which can lead to various pathological conditions in the animal organism.
Keywords: genetically modified soybean, traditional soybeans, urea, creatinine, uric acid , nitrogen metabolism , total protein, GM soy, traditional soya, rat, rats, rodent, rodents
Citation:
Chorna, I., 2019. Effect of glyphosate-resistant genetically modified soybeans and herbicide “roundup” on the level of some nitrogen metabolism metabolites in rat urine. Bioresources and Nature Management, 11(3-4), pp.5-15.
Category:
- Health effects
Record ID: 2784
