Journal or Publishing Institution: Iconic Research And Engineering Journals
Author(s): Shehu, A.S., Abdullahi, A.A., El-yakub, A.U. And Muhammad, M.
Article Type: Peer Reviewed Study
Abstract:
Genetically modified (GM) soybeans are
increasingly used in agriculture and food industries
worldwide. Despite their widespread application,
concerns remain regarding their potential metabolic
effects, particularly on hepatic function. This study
evaluates the effects of GM soybeans on liver
enzyme activity and antioxidant status in albino
rats. Twenty-four male Wistar rats were randomly
divided into four groups and fed different dietary
formulations over 28 days, a control diet, a non-GM
soybean diet, a low-dose GM soybean diet, and a
high-dose GM soybean diet. At the end of the
experimental period, serum levels of alanine
aminotransferase (ALT), aspartate
aminotransferase (AST), alkaline phosphatase
(ALP), and key antioxidant markers such as
superoxide dismutase (SOD), glutathione (GSH),
and catalase (CAT) were analyzed. The findings
indicated a dose-dependent alteration in the
biochemical parameters, with elevated liver enzymes
and reduced antioxidant levels observed in rats
exposed to high GM soybean content. These results
suggest potential hepatotoxic and oxidative effects
associated with prolonged consumption of
genetically modified soybeans. The study highlights
the need for rigorous toxicological evaluation of
GM foods to ensure public health safety.
Keywords: Genetically modified Soybean; Wistar rats; Liver enzymes; Oxidative stress; Antioxidant status.
Citation:
Shehu, A.S., Abdullahi, A.A., El-yakub, A.U. And Muhammad, M., 2025. Evaluating The Metabolic Effects Of Genetically Modified Soybeans On Liver Enzymes And Antioxidants Level In Rats. Iconic Research And Engineering Journals, Volume 9 Issue 2, 1199-1207
Category:
- Health effects
Record ID: 2892
