Journal or Publishing Institution: Aquaculture
Study: https://www.sciencedirect.com/science/article/abs/pii/S0044848625002005
Author(s): Niu, R.G., Yin, C.M., Si, J.Y., Tang, M.D. and Lan, J.F.
Article Type: Peer Reviewed Study
Abstract:
Glyphosate is the most widely used herbicide in the world, and it has been detected in aquatic environments. However, the toxicity mechanism of glyphosate is not fully understood, especially its target in animals. This study investigates the impact of glyphosate exposure on Procambarus clarkii (crayfish) and explores the underlying biological mechanisms. The results demonstrate that glyphosate exposure significantly alters crayfish behavior and causes histopathological damage. Further analysis revealed that glyphosate exposure induces hypoxia and notably reduces the expression of hemocyanin (HMC). Glyphosate was found to directly bind to hemocyanin, potentially reducing its oxygen-carrying capacity. Glyphosate exposure activated the MAPK-AP1 signaling pathway, which subsequently modulated the transcription of hemocyanin subunits through the transcription factor AP1, likely playing a role in the regulation of hemocyanin production. Glyphosate exposure also disrupted the microbial composition of crayfish hemolymph, affecting both microbial load and diversity. This study provides novel insights into the complex toxicological effects of glyphosate on crayfish, revealing its interference with hemocyanin function and microbiome composition, and underscores the need for further research into its broader ecological consequences.
Keywords: glyphosate, hypoxia, crustaceans
Citation:
Niu, R.G., Yin, C.M., Si, J.Y., Tang, M.D. and Lan, J.F., 2025. Exposure to glyphosate causes hypoxia in crustaceans by targeting hemocyanin. Aquaculture, 602, p.742314.
Category:
- Health effects
- Environmental effects
Record ID: 2819
