Journal or Publishing Institution: Pakistan Veterinary Journal
Date of Publication: 04/23/2019
Study: https://web.archive.org/web/20190829182424/http://www.pvj.com.pk/in_press/18-454.pdf
Author(s): Hussain, R., Ali, F., Rafique, A., Ghaffar, A., Jabeen, G., Rafay, M., Liaqat, S., Khan, I., Malik, R., Khan, M.K. and Niaz, M.
Article Type: Peer Reviewed Study
Abstract:
Current experimental study was aimed to find out the clinico-hematological, serum
biochemical and DNA damage impacts of commonly used herbicide (glyphosate)
on non-target adult cockerels. Therefore, a total of 25 cockerels were randomly
placed in wire cages in five different groups each containing five birds. After seven
days of acclimatization, glyphosate-based herbicide was administered to cockerels
of groups (B-E) @ 50, 75, 100 and 125 mg/kg BW respectively except group A
(control) for 45 days. Blood and serum was collected at 15, 30 and 45 day of the
trial from each cockerel. The treated birds at higher doses indicated different
clinical signs such as ruffled feather, dullness, tremors, anemic wattle and comb,
depression and reduced frequency of crowing. Feed consumption and body mass
was significantly (P≤0.05) lowered in cockerels exposed to higher doses of
herbicide. The hematological parameters including red blood cell counts, hematocrit
and hemoglobin was significantly lower in treated cockerels. Results on different
biochemical parameters showed significantly lower quantity of total proteins and
albumin while significantly higher concentrations of liver function tests (alanine
aminotransferase, aspartate aminotransferase, alkaline phosphate), kidney function
tests (urea and creatinine), cardiac biomarkers (CK-Mb, triglycerides, cholesterol)
and oxidative stress parameter (malondialdehyde) of treated cockerels in dose and
time dependent manner. Results indicate that the frequency of cells with tail DNA
was significantly (P≤0.001) in exposed cockerels. The findings of the study
suggested that long term exposure of glyphosate induces adverse clinicohematological, serum biochemical and genotoxic effects on birds.
Keywords: body weight, cockerels, glyphosate, pesticides, herbicides, Roundup, hematology, serum biochemistry, exposure, genotoxicity, toxicity
Citation:
Hussain, R., Ali, F., Rafique, A., Ghaffar, A., Jabeen, G., Rafay, M., Liaqat, S., Khan, I., Malik, R., Khan, M.K. and Niaz, M., 2019. Exposure to Sub-Acute Concentrations of Glyphosate Induce Clinico-Hematological, Serum Biochemical and Genotoxic Damage in Adult Cockerels. Pakistan Veterinary Journal, 39(2), pp.181-186.
Category:
- Environmental effects
- Pesticide use
Record ID: 2501
