Feeding study with Bt corn (MON810: Ajeeb YG) on rats: Biochemical analysis and liver histopathology

Journal or Publishing Institution: Food and Nutrition Sciences

Date of Publication: 03/01/2013

Study: http://iosrjournals.org/iosr-jac/papers/vol4-issue1/L0415560.pdf

Author(s): Abdo, E.M., Barbary, O.M., and Shaltout, O.E.S.

Article Type: Peer Reviewed Study

Abstract:

Bt corn “MON810: Ajeeb YG” produces delta endotoxins in the whole plant due to the genetic modification process. The chemical analysis of this variety showed significant differences from its conventional counterpart“Ajeeb”. Further, feeding studies on rats were designed to complete assessing the safety of “MON810: Ajeeb YG”. Three groups of rats (6 males and 6 females’ rats/group) were fed on control diet, non-Bt corn and Bt corn for 1.5 months and 3 months. After 1.5 months, 3 males and 3 females from each group were sacrificed, and after another 1.5 months, 3 males and 3 females from each group and their offspring were sacrificed. Histopathological examination, blood haematology and serum biochemical analysis were determined. Results indicated significant differences among the tested parameters in the three groups especially Bt group. Severe changes in the liver of Bt group after 3 months were observed.

Keywords: genetically modified (GM) maize, genetically modified (GM) corn, Bt corn, Bt crops, Bacillus thuringienus, Bt toxin, Cry proteins, Cry toxins, MON810, pesticides, insecticides, genetically engineered (GE), GMO, transgenic crops, feeding study, compositional chemical analysis, endotoxins, safety assessment, rats, hepatotoxicity, liver, rodent, rodents, rat

Citation:

Abdo, E.M., Barbary, O.M., and Shaltout, O.E.S., 2014. Feeding Study with Bt Corn (MON810: Ajeeb YG) on Rats: Biochemical Analysis and Liver Histopathology. Food and Nutrition Sciences, 5(2), 185.

Category:

• Health effects

Record ID: 3