Journal or Publishing Institution: European Journal of Histochemistry
Study: http://www.ncbi.nlm.nih.gov/pubmed/14706936
Author(s): Malatesta, M., Biggiogera, M., Manuali, E. and Rocchi, M.B.
Article Type: Peer Reviewed Study
Abstract: We carried out ultrastructural morphometrical and immunocytochemical analyses on pancreatic acinar cell nuclei from mice fed on genetically modified (GM) soybean, in order to investigate possible structural and molecular modifications of nucleoplasmic and nucleolar constituents. We found a significant lowering of nucleoplasmic and nucleolar splicing factors as well as a perichromatin granule accumulation in GM-fed mice, suggestive of reduced post-transcriptional hnRNA processing and/or nuclear export. This is in accordance to already described zymogen synthesis and processing modifications in the same animals.
Keywords: Cell Nucleus, Exocrine Pancreas, Genetically Modified Soybean, Splicing Factors; Animals, Cell Nucleolus, Diet, Female, Genetically Modified Food, Mice, Pancreas, Genetically Modified Plants, Pregnancy, RNA Splicing, Reproduction, Soybeans; Genetics, Drug Effects, Ultrastructure, Adverse Effects, Pathology
Citation: Malatesta, M., Biggiogera, M., Manuali, E. and Rocchi, M.B., 2009. Fine structural analyses of pancreatic acinar cell nuclei from mice fed on genetically modified soybean. European Journal of Histochemistry, 47(4), pp.385-388.
