Hematological, biochemical and histo-pathological evaluation of the transgenic corn and Cry1Ab protein effect on mice diet

Journal or Publishing Institution: Universidade Federal de Pelotas

Study: https://web.archive.org/web/20180812134028/http://livros01.livrosgratis.com.br/cp023725.pdf

Author(s): Venzke, J.G.

Article Type: Peer Reviewed Study

Record ID: 1554

Abstract: In order to developing a methodology evaluating the alimentary security of transgenic products, it has been done a ninety-days study using thirty-two BALB/c mice aging 6 to 8 weeks, where transgenic with Cry1Ab, an insecticide protein against Lepidoptera bugs was used. The animals were divided in four groups of eight; and received control diet (0%), 10% transgenic corn diets (10%), 30% transgenic corn diets (30%), and the endotoxin from Cry1Ab, commercially used for spraying the crops (Cry1Ab). The hematological results did not presented alterations. The biochemical and histo-pathological data indicate that has been hepatic injuries in the mice fed with the Cry1Ab protein, 10% and 30% transgenic corn diets, when compared with the control groups.

Keywords: food safety, transgenic, Cry1ab, nutritional assessment

Citation: Venzke, J.G., 2006. Hematological, biochemical and histo-pathological evaluation of the transgenic corn and Cry1Ab protein effect on mice diet (Doctoral dissertation, Dissertação (Mestrado)–Universidade Federal de Pelotas. 2006.