Journal or Publishing Institution: Turkiye Klinikleri Journal of Pharmacy Sciences
Author(s): Sarialtin, S.Y. and Çoban, T.
Article Type: Journal Publication
Record ID: 2270
Abstract: Glyphosate used in genetically modified organism soybean and corn production. Glyphosate can lead health problems in individuals exposed the chemical occupationally and environmentally as well as air, water and food. Glyphosate (N-phosphonomethyl glycine) is a broadspectrum weedkillers (herbicide) widely used all over the world. Glyphosate is inhibited 5-enolpurivilshikimic acid-3-phosphate synthase in the shikimate pathway in bacteria, archebacteria and plants resulting in suppression of the synthesis of aromatic amines such as tyrosine and tryptophan. Glyphosate has been used safely for many years as there were no studies showing an association between glyphosate exposure and the occurrence of any disease. However, recent studies has showed that this herbicide may play a role in the development of neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease, autoimmune diseases such as ulcerative colitis, Crohn’s disease, obesity, infertility and cancer. World Health Organization International Agency for Research on Cancer has evaluated several studies and classified glyphosate as Group 2A “probably carcinogenic to humans” in March of 2015. Moreover, toxicity of glyphosate-based herbicides may increase due to the adjuvants. The toxic effects of glyphosates are reported by several in vivo and in vitro studies, however new studies are needed to clarify the exact mechanisms.
Keywords: Glyphosate; herbicides; pesticides
Citation: Sarialtin, S.Y. and Çoban, T., 2017. Human health risks of the use of glyphosate and glyphosate-based herbicides: Review. Turkiye Klinikleri Journal of Pharmacy Sciences, 6(1), pp.1-14.
