Journal or Publishing Institution: Toxicological & Environmental Chemistry
Study: http://www.tandfonline.com/doi/abs/10.1080/02772248.2013.863889#.U6LtevldXMJ
Author(s): Fan, J., Geng, J., Ren, H., and Wang, X.
Article Type: Peer Reviewed Study
Record ID: 661
Abstract: Oxidative stress parameters and some antioxidant defense systems in the liver of Carassius auratus exposed to glyphosate and its formulation (Roundup®) have been studied. Fish were exposed to glyphosate and its formulation at concentrations of 0.032, 0.16, 0.8, and 4.0 mg L−1, all calculated on glyphosate basis, for 11 days. Hydroxyl radical generation as determined by electron spin resonance spectroscopy of its spin-adduct with α-phenyl-t-butyl nitrone increased with the concentration of Roundup®. Superoxide dismutase activities were decreased relative to control by 21%–46% when exposed to glyphosate and 45%–52% when exposed to Roundup®, suggesting that the formulation is more toxic than glyphosate alone. Catalase showed no difference between both groups.
Keywords: Carassius auratus, glyphosate, Roundup®, hydroxyl radical (·OH), antioxidant defenses
Citation: Fan, J., Geng, J., Ren, H., and Wang, X., 2013. Hydroxyl radical generation and oxidative stress in Carassius auratus exposed to glyphosate and its formulation. Toxicological & Environmental Chemistry, 95(7).
