Journal or Publishing Institution: Trends in Biotechnology
Study: http://www.ncbi.nlm.nih.gov/pubmed/9263477
Author(s): Doerfler, W., Schubbert, R., Heller, H., Kämmer, C., Hilger-Eversheim, K., Knoblauch, M. and Remus, R.
Article Type: Journal Publication
Record ID: 517
Abstract: The insertion of foreign DNA into the genomes of established cells and organisms and the consequences of this integration event are of significance for viral oncology, reverse genetics, transgenic organisms, human somatic gene therapy and evolution. This review summarizes recent experimental findings and focuses on the alteration of cellular DNA methylation at regions remote from the site of insertion. We also discuss experimental data demonstrating that foreign DNA ingested by mice is not completely degraded in their gastrointestinal tracts; fragments of this DNA have been found to be covalently linked to DNA with 70% homology to the mouse IgE receptor gene.
Keywords: foreign DNA, cellular DNA methylation
Citation: Doerfler, W., Schubbert, R., Heller, H., Kämmer, C., Hilger-Eversheim, K., Knoblauch, M. and Remus, R., 1997. Integration of foreign DNA and its consequences in mammalian systems. Trends in Biotechnology, 15(8), pp.297-301.
