Metabolism of 2,4-dichlorophenoxyacetic acid in laying hens and lactating goats

Journal or Publishing Institution: Journal of Agricultural and Food Chemistry

Date of Publication: 12/20/2000

Study: http://www.ncbi.nlm.nih.gov/m/pubmed/11170571/

Author(s): Barnekow, D.E., Hamburg, A.W., Puvanesarajah, V. and Guo, M.

Article Type: Peer Reviewed Study

Abstract:

2,4-Dichlorophenoxyacetic acid (2,4-D) labeled with (14)C was found to be rapidly eliminated by laying hens and lactating goats dosed orally for 7 consecutive days at 18 mg/kg of food intake and for 3 consecutive days at 483 mg/kg of food intake, respectively. Excreta of hens and goats contained >90% of the total dose within 24 h after the final dose. Tissue residues were low and accounted for <0.1% of the dose in these animals. For hens, the residues in muscle, liver, and eggs (0.006-0.030 ppm) were lower than those found in fat and kidney (0.028-0.714 ppm), 2,4-D equivalents. The tissue with highest residue in goat was the kidney at 1.44 ppm, 2,4-D equivalents. Milk, liver, composite fat, and composite muscle had significantly lower residue levels of 0.202, 0.224, 0.088, and 0.037 ppm, respectively. The most abundant tissue residue was 2,4-D and acid/base releasable residues of 2,4-D. A minor metabolite was identified as 2,4-dichlorophenol.

Keywords: 2,4-Dichlorophenoxyacetic acid (2,4-D), laying hens, lactating goats, metabolism, herbicides, pesticides

Citation:

Barnekow, D.E., Hamburg, A.W., Puvanesarajah, V. and Guo, M., 2001. Metabolism of 2, 4-dichlorophenoxyacetic acid in laying hens and lactating goats. Journal of Agricultural and Food Chemistry, 49(1), pp.156-163.

Category:

• Health effects
• Environmental effects
• Pesticide use

Record ID: 137