Journal or Publishing Institution: Bulletin of Environmental Contamination and Toxicology
Study: http://link.springer.com/article/10.1007/s00128-013-1103-7
Author(s): De Souza Filho, J., Sousa, C.C.N., Da Silva, C.C., De Sabóia-Morais, S.M.T., and Grisolia, C.K.
Article Type: Peer Reviewed Study
Record ID: 497
Abstract: Poecilia reticulata were exposed to herbicide Roundup Transorb® for micronucleus test, nuclear abnormalities and comet assay. The exposure-concentrations were based on CL50–96 h following 0, 1.41, 2.83, 4.24 and 5.65 μL L−1 for 24 h. Micronucleus and comets were significantly increased in the gill erythrocyte cells after herbicide exposure compared with the non-exposed group. Results showed a gradual increase in the number of damaged cells, indicating a concentration-dependent effect and that this herbicide was mutagenic and genotoxic to P. reticulata and this effect could be attributed to a combination of compounds contained in the formulation with the active ingredient glyphosate.
Keywords: Roundup Transorb®, Comet assay, Micronucleus, Glyphosate formulations, Fish, Poecilia reticulata
Citation: De Souza Filho, J., Sousa, C.C.N., Da Silva, C.C., De Sabóia-Morais, S.M.T., and Grisolia, C.K., 2013. Mutagenicity and genotoxicity in gill erythrocyte cells of Poecilia reticulata exposed to a glyphosate formulation. Bulletin of Environmental Contamination and Toxicology, 91(5), 583-587.