Journal or Publishing Institution: Biohelikon: Cell Biology
Study: https://web.archive.org/web/20180728183210/https://www.biohelikon.org/manuscript/2348-3741-2-a14.pdf
Author(s): Hassanane, M.M., Kassem, S.M., and Eltoukhy, S.E.
Article Type: Peer Reviewed Study
Record ID: 937
Abstract: Glyphosate (N-(phosphonomethyl) glycine, C3 H8 NO5P) is the world’s most widely used herbicide. Nevertheless their benefits, occupational and environmental exposure to pesticides can pose a threat to non-target species including human beings. Numerous laboratory studies have shown that Glyphosate and the roundup formulation can be genotoxic and endocrine disrupting. Therefore, the present study was undertaken to evaluate the genotoxic and biochemical effects ofGlyphosate as well as the protective effects of orange juice against these alterations in Swiss albino male mice. Animals were administered orally with the pesticide and/or orange juice for a period of 2 and 4 weeks and divided into 4 groups (10 animals each) as follows: The 1 st group served as control, the 2 nd group was treated with orange juice, the 3rd group was treated with pesticide Glyphosate and the 4th group was treated with pesticide in combination with orange Juice. The results revealed that treatment with Glyphosate induced DNA damage, micronucleus formation and chromosomal aberrations in bone marrow and spermatocyte cells, as well DNA fragmentation potentially by increasing generation offree radicals which are reconvened by orange juice treatment as a protective agent. The biochemical parameters (malondialdehyde levels, MDA) were increased significantly in the Glyphosate treated groups, whereas the combination with orange juice reduced that elevation in these parameters. In conclusion, Glyphosate appears to have the ability to cause genetic damage and biochemical alterations in the treated mice. The protective role of orange juice could be attributed to its antioxidant properties.
Keywords: Glyphosate, Genotoxic, Biochemical Alterations, Protective, Orange Juice, Mice, Mouse, Rodent, Rodents
Citation: Hassanane, M.M., Kassem, S.M., and Eltoukhy, S.E., 2014. Orange juice reduced genetic and biochemical alterations induced by herbicide Glyphosate in mice. Biohelikon: Cell Biology, 2(a14): 2348-3741.
