Journal or Publishing Institution: Chemosphere
Study: http://www.sciencedirect.com/science/article/pii/S0045653517310731
Author(s): de Moura, F.R., Brentegani, K.R., Gemelli, A., Sinhorin, A.P., and Sinhorin, V.D.G.
Article Type: Peer Reviewed Study
Record ID: 482
Abstract: The aim of this study was to investigate the effects of Roundup Original®, a glyphosate-based herbicide, against biochemical parameters including thiobarbituric acid-reactive substances (TBARS), protein carbonyl, enzymatic and nonenzymatic antioxidant responses and acetylcholinesterase (AChE) of jundiara fish (Leiarius marmoratus × Pseudoplatystoma reticulatum) at a sublethal concentration of 1.357 mg L−1. Fish exposed to the herbicide for different periods (6–96 h) showed a significant increase of both hepatic and muscular TBARS and protein carbonyl. Enzymatic antioxidant activity was decreased in the liver and brain after 48 h of exposure. Glutathione-S-tranferase (GST) had its levels raised in the brain and gills, probably as a toxicity event response. Non protein thiols (GSH) demonstrated a reduction after 6 and 24 h of exposure in the hepatic tissue, followed by an increase at 48 and 96 h in the same tissue. GSH brain levels, however, increased only after 96 h. AChE activity in muscle decreased for all the times tested (26.5, 45, 38 and 14% for 6, 24, 48 and 96 h respectively), but only at 96 h (34%) in the brain. We found that Roundup Original® is able to trigger important changes in the biochemical parameters tested, showing it can be a potential threat for the health and survival of fish in the environment.
Keywords: Antioxidants, Glyphosate, Hybrid fish, Toxicity
Citation: de Moura, F.R., Brentegani, K.R., Gemelli, A., Sinhorin, A.P., and Sinhorin, V.D.G., 2017. Oxidative stress in the hybrid fish jundiara (Leiarius marmoratus× Pseudoplatystoma reticulatum) exposed to Roundup Original®. Chemosphere, 185, 445-451.
