Journal or Publishing Institution: Discover Applied Sciences
Study: https://link.springer.com/article/10.1007/s42452-025-06985-4
Author(s): Babatunde, I.O., Adebisi, O.A., Adenmosun, A.B., Adeyeye, A.A., Aremu, H.K. and Adewale, O.O.
Article Type: Peer Reviewed Study
Abstract:
Background
Nephrotoxicity, oxidative stress, and inflammation have all been connected to pesticide and xenobiotic exposure. Here, we evaluate the protective potential of Xylopia aethiopica stem-bark ethanol extract (XASEE) on glyphosate-induced nephrotoxicity in Wistar rats.
Method
The plant stem-bark was subjected to cold maceration in 50% ethanol and the obtained extract was lyophilized. The phytochemicals in the extract were analysed while Lorke’s method was used for its acute toxicity study. In a 7 day study, rats (36) were grouped into six (n = 6 each) and treated as follows; control, glyphosate (150 mg/kg b.wt), glyphosate + XASEE (1/10 th of extract -LD50), glyphosate + vitamin C (250 mg/kg), XASEE and vitamin C only.
Results
Phytochemical analysis indicated saponins, tannins, phenolics, flavonoids, glycosides, steroids, and alkaloids. Phenolics have the highest level (492.84 ± 0.01 mg/100 g) while glycosides were least (7.01 ± 0.02 mg/100 g) in XASEE. The estimated LD50 was 1264.91 mg/kg b.wt. Oral exposure of rats to glyphosate significantly increased the concentrations of creatinine, urea, and uric acid in the serum and the level of MDA, NO, creatinine, IL-6 and TNF-α in kidney homogenate. Also, there was a decrease in antioxidant enzymes activities of GPX, SOD, GSH, and CAT with no significant alteration in the concentration of serum electrolytes (K+, Na+, Cl−, and HCO3− ions) in glyphosate group compared to the control. Meanwhile, co-administration of XASEE after 2 h of administration of glyphosate ameliorate this incidence of nephrotoxicity, lipid peroxidation and inflammation.
Conclusion
The result shows XASEE confers protective attributes against glyphosate-induced nephrotoxicity, oxidative stress, and inflammation.
Keywords: Nephrotoxicity, Glyphosate , Xylopia aethiopica, Nephroprotective , Organophosphorus
Citation:
Babatunde, I.O., Adebisi, O.A., Adenmosun, A.B., Adeyeye, A.A., Aremu, H.K. and Adewale, O.O., 2025. Phytochemical, acute toxicity and protective role of Xylopia aethiopica stem-bark ethanol extract (XASEE) on glyphosate-induced nephrotoxicity in Wistar Rat. Discover Applied Sciences, 7(10), pp.1-16.
Category:
- Health effects
Record ID: 2800
