The impact of simultaneous intoxication with agrochemicals on the antioxidant defense system in rat

Journal or Publishing Institution: Pesticide Biochemistry and Physiology

Study: http://www.sciencedirect.com/science/article/pii/S004835750900039X

Author(s): Astiz, M., de Alaniz, M.J. and Marra, C.A.

Article Type: Peer Reviewed Study

Record ID: 1511

Abstract: It is known that the presence of pesticides may alter the reproductive performance of animals. We studied the effect of chronic pesticide exposure in rats injected i.p. for 5 weeks with doses between 1/50 and 1/250 LD50 of dimethoate, glyphosate and zineb, either alone or in combination. All tested agrochemicals increased the oxidative stress status in the plasma, liver, and testes, and also modified hormonal parameters involved in reproductive function. The increase in oxidative stress and damage biomarker levels, as well as the alteration of the antioxidant defence system decreased testosterone, FSH and LH levels in the plasma of pesticide-treated rats. These effects were more pronounced when pesticides were administered in combination, and should be considered indicative of involuntary exposure to residual agrochemicals.

Keywords: Dimethoate, Glyphosate, Zineb, Oxidative Stress, Male Reproductive System, Rats, Chronic Exposure; Chronic Toxicity, Animal Models, Enzyme Activity, Zineb, Biomarkers, Antioxidant Activity, Reproductive Toxicology, Pesticide Mixtures, Animal Reproduction; Adverse Effects, Agricultural Chemicals, Antioxidants, Blood Plasma, Defence Mechanisms, Exposure, FSH, Fungicides, Herbicides, Insecticdes, LH, Liver, Oxidation, Testes, Testosterone; Adverse Reactions, Agrochemicals, Defense Mechanisms, Follicile Stimulating Hormone, Follitropin, Fungistats, Luteinizing Hormone, Plasma (Blood), Testicles, Weedicides, Weedkillers

Citation: Astiz, M., de Alaniz, M.J. and Marra, C.A., 2009. The impact of simultaneous intoxication with agrochemicals on the antioxidant defense system in rat. Pesticide Biochemistry and Physiology, 94(2-3), pp.93-99.