Journal or Publishing Institution: Current Opinion in Cell Biology
Study: http://www.sciencedirect.com/science/article/pii/0955067495800964
Author(s): Dougherty, W.G. and Parks, T.D.
Article Type: Journal Publication
Record ID: 547
Abstract: Transgenes provide unique opportunities to assess the relationship between genotype and phenotype in an organism. In most cases, introduction and subsequent expression of a transgene will increase (with a sense RNA) or decrease (with an antisense RNA) the steady-state level of a specific gene product. However, a number of surprising observations have been made in the course of many transgenic studies. We develop a hypothesis that suggests that many examples of endogenous gene suppression by either antisense or sense transcripts are mediated by the same cellular mechanism.
Keywords: transgenes, sense RNA, antisense RNA, endogenous gene suppression
Citation: Dougherty, W.G. and Parks, T.D., 1995. Transgene and gene suppression: telling us something new? Current Opinion in Cell Biology, 7(3), pp.399-405.
