Search Results for: Immune
Innate immune changes in the peripheral blood of Chronic Fatigue Syndrome patients: Risk factors for disease progression and management
Abstract: Chronic Fatigue Syndrome (CFS) is recognized by the WHO as an alternative name for Myalgic Encephalomyelitis, which has been classified as a disease of the central nervous system since 1969. The concept that chronic microbial infection drives constant activation of the innate immune system through alterations in the production of innate immune cells and …
Intranasal, rectal and intraperitoneal immunization with protoxin Cry1Ac from Bacillus thuringiensis induces compartmentalized serum, intestinal, vaginal and pulmonary immune responses in Balb/c mice
Abstract: Recently we discovered that the Cry1Ac protoxin of Bacillus thuringiensis administered to Balb/c mice intraperitoneally (i.p.) or intragastrically is a systemic and intestinal immunogen as potent as cholera toxin. To further characterize the mucosal immunogenicity of Cry1Ac we additionally tried the intranasal (i.n.) and rectal routes and used enzyme-linked immunoassays to determine anti-Cry1Ac antibody …
Characterization of the mucosal and systemic immune response induced by Cry1Ac protein from Bacillus thuringiensis HD 73 in mice
Abstract: The present paper describes important features of the immune response induced by the Cry1Ac protein from Bacillus thuringiensis in mice. The kinetics of induction of serum and mucosal antibodies showed an immediate production of anti-Cry1Ac IgM and IgG antibodies in serum after the first immunization with the protoxin by either the intraperitoneal or intragastric …
The effects of Roundup® and Cosmoflux® 411f on the immune response of white cachama (Piaractus brachypomus) challenged with Aeromonas hydrophila
Abstract: It has been showed herbicides affect organisms which were not the target for their action. Such effects would include endocrine alteration, as well as teratogenesis and damage to the respiratory, digestive, and immune and nervous systems. It has been documented that alterations to the immune system could produce significant effects on a fish’s ability …
Effect of foreign (not self) DNA/RNA on the human immune system in regard to genetically modified plants
Abstract: This review shall give policy makers and risk managers the rational basis to widen the view on the risk assessment of genetically modified plants and therefore to include potential impacts associated with synthetic DNA/RNA fragments of genetically modified plants to the human immune system. Such risks are so far excluded form the risk assessment …
Intestinal and peripheral immune response to MON810 maize ingestion in weaning and old mice
Abstract: This study evaluated the gut and peripheral immune response to genetically modified (GM) maize in mice in vulnerable conditions. Weaning and old mice were fed a diet containing MON810 or its parental control maize or a pellet diet containing a GM-free maize for 30 and 90 days. The immunophenotype of intestinal intraepithelial, spleen, and …
Effects of edifenphos and glyphosate on the immune response and protein biosynthesis of bolti fish (Tilapia nilotica)
Abstract: The effects of 1/1000 field recommended concentration of the organophosphorus compounds; edifenphos and glyphosate on the immune response and protein contents were investigated after different time intervals. The cell mediated immune response assessed by proliferative response of splenocytes to mitogens; phytohemagglutinin (PHA) and concanavalin A (Con A) for T cell and lipopolysaccharide (LPS) for …
The effect of multigenerational diet containing genetically modified triticale on immune system in mice
Abstract: The safety assessment of genetically modified (GM) food and feed is performed to identify the possible effects upon animal and human health, also the long-term, multigenerational influence upon functioning of different organs and systems, such as the immune system. In this study C57BL/6J mice were fed for five consecutive generations with pellets containing 20% …
Evaluation of stress‐ and immune‐response biomarkers in Atlantic salmon, Salmo salar L., fed different levels of genetically modified maize (Bt maize), compared with its near‐isogenic parental line and a commercial suprex maize
Abstract: The present study was designed to evaluate if genetically modified (GM) maize (Bt maize, event MON810) compared with the near‐isogenic non‐modified (nGM) maize variety, added as a starch source at low or high inclusions, affected fish health of post‐smolt Atlantic salmon, Salmo salar L. To evaluate the health impact, selected stress‐ and immune‐response biomarkers …
Effects of oral Bt-maize (MON810) exposure on growth and health parameters in normal and sensitised Atlantic salmon, Salmo salar L
Abstract: Responses to GM maize Bt-maize, MON810) expressing Cry1Ab protein from the soil bacterium Bacillus thuringiensis (Bt) in diets for both normal and immune-sensitised (with soyabean meal (SBM)-induced enteropathy) post-smolt Atlantic salmon were investigated following 33 and 97 d of exposure. Triplicate tanks of salmon were fed one of four diets, all containing 20% whole-kernel …
Microbiological identification microbiocenosis and the immune status of laboratory rodents while feeding them genetically modified fodder
Abstract: Приведены данные по показателям микробиологической диагностики микробиоценоза, неспецифической реактивности и иммунной системы у лабораторных крыс и мышей при кормлении их ГМО кормами. Keywords: GM soy, Genetically modified soybean, Transgenic soybeans, Mice, Rats, Rodent, Erythrocytes, Leukocytes, Lymphocytes, T-lymphocytes, B-lymphocytes, Killer cells, Stab neutrophils, Segmented neutrophils, Phagocytic activity of neutrophils, Phagocytic number, Bactericidal activity, Lysozyme activity, …
Exposure to sublethal concentration of glyphosate or atrazine-based herbicides alters the phagocytic function and increases the susceptibility of silver catfish fingerlings (Rhamdia quelen) to Aeromonas hydrophila challenge
Abstract: The resistance of fish to microorganisms challenge depends mainly on the efficacy of the immune response. Most studies on the natural immune response of fish have focused on the effect of diets and immunostimulants. Few studies correlated the presence of commonly used agrichemical and susceptibility to infection by aquatic microorganism. Thus, this study aimed …
Fast food fever: reviewing the impacts of the Western diet on immunity
Abstract: While numerous changes in human lifestyle constitute modern life, our diet has been gaining attention as a potential contributor to the increase in immune-mediated diseases. The Western diet is characterized by an over consumption and reduced variety of refined sugars, salt, and saturated fat. Herein our objective is to detail the mechanisms for the …
Exploring the obesity epidemic
Text: In our lifetime we are experiencing never before seen rates of obesity, with a 68% rate of overweight in adults. In my field of gynecologic oncology, our surgical cases have become tremendously challenging due to the large size of our patients. When I was in residency training in the mid 1980s, it was rare …
Altered hematological and immunological parameters in silver catfish (Rhamdia quelen) following short term exposure to sublethal concentration of glyphosate
Abstract: Using agrichemicals to control unwanted species has become a necessary and common worldwide practice to improve crop production. Although most currently used agrichemicals are considered relatively safe, continuous usage contributes for soil and water contamination and collateral toxic effects on aquatic species. Few studies correlated the presence of agrichemicals on fish blood cells and …
Expression of mouse interleukin-4 by a recombinant ectromelia virus suppresses cytolytic lymphocyte responses and overcomes genetic resistance to mousepox
Abstract: Genetic resistance to clinical mousepox (ectromelia virus) varies among inbred laboratory mice and is characterized by an effective natural killer (NK) response and the early onset of a strong CD8(+) cytotoxic T-lymphocyte (CTL) response in resistant mice. We have investigated the influence of virus-expressed mouse interleukin-4 (IL-4) on the cell-mediated response during infection. It …
Glyphosate pathways to modern diseases VI: Prions, amyloidoses and autoimmune neurological diseases
Abstract: Usage of the herbicide glyphosate on core crops in the USA has increased exponentially over the past two decades, in step with the exponential increase in autoimmune diseases including autism, multiple sclerosis, inflammatory bowel disease, type 1 diabetes, coeliac disease, neuromyelitis optica and many others. In this paper we explain how glyphosate, acting as …
Determination of protein allergenicity: studies in rats
Abstract: For the safety evaluation of genetically engineered crops the potential allergenicity of the newly introduced protein(s) has become an important issue. There is, however, no universal and reliable test system for the evaluation of the allergenic potency of food products. The best known allergy assessment proposal is the careful stepwise process using the IFBC/ILSI …
