Search Results for: Testosterone

Abstract: Glyphosate is a herbicide widely used to kill weeds both in agricultural and non-agricultural landscapes. Its reproductive toxicity is related to the inhibition of a StAR protein and an aromatase enzyme, which causes an in vitro reduction in testosterone and estradiol synthesis. Studies in vivo about this herbicide effects in prepubertal Wistar rats reproductive …

Text: Влияние диеты, содержащей генетически модифицированную (ГМ) сою, на репродуктивные функции животных изучено недостаточно. Имеющиеся в литературе данные противоречивы. Так, Brake и Evenson [1] не выявили негативного воздействия наиболее распространенной ГМ-сои устойчивой к гербициду раундапу в результате внедрения трансгена EPSPS CP4 (RR, линия 40.3.2), на сперматогенез у потомства самцов мышей. В то же время в …

Abstract: The product used in our study was a commercial formulation of glyphosate Roundup Transorb (Monsanto, Brazil). In previous studies, we and other colleagues used different commercial formulations and observed a reduction in testosterone concentrations or reduction in StAR protein expression (Benachour et al. 2007; Benachour and Seralini 2009; Dallegrave et al. 2007; Gasnier et al. …

Abstract: Sexual differentiation in the brain takes place from late gestation to the early postnatal days. This is dependent on the conversion of circulating testosterone into estradiol by the enzyme aromatase. The glyphosate was shown to alter aromatase activity and decrease serum testosterone concentrations. Thus, the aim of this study was to investigate the effect …

Abstract: Oral administration of 2,4-dichlorophenoxyacetic butyl ester (2,4-Dbe) at a dose of 69 mg/kg/day to nulliparous females had no deleterious effects on either open field (OF) and rotarod performance. By contrast, dams treated with 2,4-Dbe during pregnancy exhibited impairments of OF activity, rotarod performance and improved active avoidance learning (AAL) retention. Administration of 2,4-Dbe to …

Abstract: This work was carried out to verify the effect of a glyphosate-based herbicide on Jundiá hormones (cortisol, 17β-estradiol and testosterone), oocyte and swim-up fry production. Earthen ponds containing Jundiá females were contaminated with glyphosate (3.6mg/L); blood samples were collected from eight females from each treatment immediately before, or at 1, 10, 20, 30 and …

Abstract: The incidence of infertility in human is on the increase and the use of Roundup herbicide and presence of its residues in foodstuff is a major concern. This study therefore aim to assess the effect of Roundup on the reproductive capacity of 32 adult male albino rats randomized into 4 groups of 8 rats …

Abstract: Atrazine (AZ) and glyphosate (GL) are herbicides that are widely applied to cereal crops in Egypt. The present study was designed to investigate the response of the snail Biomphalaria alexandrina (Mollusca: Gastropoda) as a bioindicator for endocrine disrupters in terms of steroid levels (testosterone (T) and 17β-estradiol (E)), alteration of microsomal CYP4501B1-like immunoreactivity, total …

Abstract: Lactose intolerance is characterized by low or inexistent levels of lactase, and the main treatment consists of dietary changes, especially replacing dairy milk by soy milk. Soy contains phytoestrogens, substances with known estrogenic activity, besides, glyphosate-based herbicides are extensively used in soy crops, being frequently a residue in soy beans, bringing to a concern …

Abstract: Exposure to the Roundup has been shown to affect StAR protein and aromatase expression and activity, pointing out that this herbicide may cause adverse effects in animal reproduction by affecting androgen and estrogen synthesis. We tested this hypothesis by investigating the in vivo effects of the Roundup on the testis and epididymal region of …

Abstract: Glyphosate is a broad spectrum herbicide. Fruits and vegetables improve health and a diminish chronic degenerative processes. This study aims to investigate orange juice protective role against the toxicity of glyphosate induced in mice. Fifty six adult male albino mice divided into seven groups. Oral administration of glyphosate caused a significant increase in MDA …

Abstract: Background Many agricultural contaminants disrupt endocrine systems of wildlife. However, evidence of endocrine disruption in wild amphibians living in agricultural areas has been controversial. Typically, studies on the effects of pollutants on wildlife attempt to compare polluted with unpolluted sites. Objectives We took a novel approach to address this question by explicitly quantifying the …

Abstract: It is known that the presence of pesticides may alter the reproductive performance of animals. We studied the effect of chronic pesticide exposure in rats injected i.p. for 5 weeks with doses between 1/50 and 1/250 LD50 of dimethoate, glyphosate and zineb, either alone or in combination. All tested agrochemicals increased the oxidative stress …

Abstract: The effects of cypermethrin, copper and glyphosate on the endocrine system and subsequent response to female pheromones were investigated in mature male brown trout (Salmo trutta) parr. Responses measured were the amount of strippable milt, blood plasma levels of both an androgen (11-ketotestosterone (11-KT)) and a progestin (17α,20β-dihydroxy-4-pregnen-3-one (17,20b-P)), and behavioural changes. This was …

Abstract: Forest pesticide applicators constitute a unique pesticide use group. Aerial, mechanical-ground, and focal weed control by application of herbicides, in particular chlorophenoxy herbicides, yield diverse exposure scenarios. In the present work, we analyzed aberrations in G-banded chromosomes, reproductive hormone levels, and polymerase chain reaction-based V(D)J rearrangement frequencies in applicators whose exposures were mostly limited …

Abstract: Glyphosate is a broad spectrum herbicide that is effective against weeds, especially in association with transgenic glyphosate resistant crop systems, and represents approximately 30% of all herbicides used in agriculture. It was demonstrated that glyphosate has an activity of endocrine-chemical disruptor (ECD) in the reproductive axis, altering the production of testosterone and causing disturbances …

Abstract: The effect of Roundup® on adrenal gland steroidogenesis and signaling pathway associated with steroid production was investigated. Doses of 10, 50, 100 and 250 mg/kg bw/d Roundup® were administered for two weeks to adult male rats. The 10 mg/kg bw/d dose which reduced circulatory corticosterone levels, but did not change food consumption and body …

Abstract: Agricultural genetically modified (GM) plants are essentially plants which contain pesticides, because they were designed to tolerate or produce pesticides. In 2011, GM crops reached 160 million hectares, with 59 % of herbicide tolerance (mainly Roundup) mostly in soybean, maize, canola, cotton, 15 % of insecticide producing varieties and 26% combining both traits (James …

Abstract: Context – Among the 134 million hectares of genetically modified plants growing worldwide in 2009, more than 99.9 % are described as pesticide plants (Clive 2009). Around 80 % are tolerant to Roundup, a glyphosate based herbicide. Its use on GMOs is thus amplified, and this phenomenon shed a new light on the problem …

Abstract: Recent reports demonstrate that many currently used pesticides have the capacity to disrupt reproductive function in animals. Although this reproductive dysfunction is typically characterized by alterations in serum steroid hormone levels, disruptions in spermatogenesis, and loss of fertility, the mechanisms involved in pesticide-induced infertility remain unclear. Because testicular Leydig cells play a crucial role …

Abstract: Hormonal and histological changes in a tissue of ovaries of rats are studied at long introduction in nutrition GMO. Introduction in nutrition within 6 months of the GMO-soya to practically healthy rats Vistar leads to an acceleration of ageing of ovaries. Keywords: GM soy, Glyphosate tolerant soybean, GTS 40-3-2, Roundup Ready soya, Wistar rats, …

Abstract: We present the long-term goals and research activities by collaborators of the ‘fishENCODE’ project, part of the global “ONE HEALTH Epigenomics Educational Initiative” (1). The goals of fishENCODE are to study the intergenerational epigenetic changes and adverse health effects to fish caused by endocrine disrupting chemicals (EDCs) such as the metal cadmium (Cd) and …

Abstract: Glyphosate is the active ingredient and polyoxyethyleneamine is the surfactant present in the herbicide Roundup formulation commercialized in Brazil. The aim of this study was to assess the reproductive effects of glyphosate-Roundup on male and female offspring of Wistar rats exposed during pregnancy and lactation. Dams were treated orally with water or 50, 150 …