GMO Research
Abstract: As a result of studies on the effect of antibiotics on quality of producing boars’ semen, the perfect dose of sanitizing agents cefotaxime, cefepime and ampicillin was determined as part of semen diluent which contributes to obtaining better results in terms of mobility, morphological and acrosome integrity of genital gametes compared to similar spectrum …
Abstract: Objective: To investigate the protective effect of different doses of tea polyphenol (TP) on the mouse sertoli cells against oxidative damage and apoptosis induced by glyphosate (GLY). Methods: The oxidative damage model of primarily cultured mouse sertoli cells was established through GLY (90mg/L) incubation for 24h. Then the cells were treated with different doses …
Abstract: Objective: To investigate the effect of different doses of glyphosate on apoptosis and expressions of androgen-binding protein (ABP) and vimentin mRNA in mouse Sertoli cells. Methods: Primarily cultured mouse Sertoli cells incubated with different doses of glyphosate (60, 90, 120, 150 and 180 mg/L) for 24 h. The growth and morphological alterations in the …
Abstract: Glyphosate-based herbicides (GBH) are the major pesticides used worldwide. Among them, the Roundup formulations are the most popular. Some aspects of GBH toxicity are well known, such as induction of oxidative stress. However, embryotoxicity is scarcely known. Therefore, the aim of the present study was to evaluate the effect of exposure to different Roundup …
Abstract: Genetically modified (GM) crops have been commercially available for human and animal consumption since the 1990s. The safety evaluations are based on the concept of substantial equivalence, which assumes that the toxicity of a product can be investigated by assessing the toxicity of individual components of the product and not the product as a …
Abstract: Soil microorganisms are highly exposed to glyphosate-based herbicides (GBH), especially to Roundup® which is widely used worldwide. However, studies on the effects of GBH formulations on specific non-rhizosphere soil microbial species are scarce. We evaluated the toxicity of a commercial formulation of Roundup® (R450), containing 450 g/L of glyphosate (GLY), on the soil filamentous …
Abstract: In the initial screening, 18 out of 32 Conyza albida and 7 out of 28 Conyza bonariensis populations, sampled from main perennial crop regions of central and southern Greece, were found to be resistant to glyphosate. The level of resistance determined in dose–response experiments with representative populations of the two species was found to …
Abstract: Background Glyphosate-based herbicides (GBH) are the major pesticides used worldwide. Converging evidence suggests that GBH, such as Roundup, pose a particular health risk to liver and kidneys although low environmentally relevant doses have not been examined. To address this issue, a 2-year study in rats administering 0.1 ppb Roundup (50 ng/L glyphosate equivalent) via …
Abstract: The impairment of liver function by low environmentally relevant doses of glyphosate-based herbicides (GBH) is still a debatable and unresolved matter. Previously we have shown that rats administered for 2 years with 0.1 ppb (50 ng/L glyphosate equivalent dilution; 4 ng/kg body weight/day daily intake) of a Roundup GBH formulation showed signs of enhanced liver injury …
Abstract: Background Glyphosate-based herbicides (GBH) are the major pesticides used worldwide. Converging evidence suggests that GBH, such as Roundup, pose a particular health risk to liver and kidneys although low environmentally relevant doses have not been examined. To address this issue, a 2-year study in rats administering 0.1 ppb Roundup (50 ng/L glyphosate equivalent) via …
Abstract: Glyphosate (N-phosphonomethyl-glycine, GLP) is the most popular herbicide used worldwide. This study aimed to investigate the effects of glyphosate on rats’ liver function and induction of pathological changes in ion levels and oxidative stress in hepatic tissue. Sprague-Dawley rats were treated orally with 0, 5, 50, and 500 mg/kg body weight of the GLP. …
Abstract: 1. The growth of interspecific hybrids between oilseed rape (Brassica napus ssp. oleifera) and hoary mustard (Hirschfeldia incana) was studied in different conditions of temperature and photoperiod in individual pots and in competitive conditions with each of the two parental species. 2. In the absence of competition, the hybrid plants were intermediate between parents …
Abstract: Glyphosate (GLP), the active ingredient of many weed killing formulations, is a broad spectrum herbicide compound. Wistar rats were exposed during 30 or 90 days to the highest level (0.7 mg/L) of GLP allowed in water for human consumption (US EPA, 2011) and a 10-fold higher concentration (7 mg/L). The low levels of exposure …
Abstract: Genetic engineering, also called genetic modification, is facing with growing demands of aquaculture and aquatic products. Although various genetically modified (GM) aquatics have been generated, it is important to evaluate biosafety of GM organisms on the human health before entering into our food chain. For this purpose, we establish a zebrafish wild adult feeding …
Abstract: In this study, we investigated whether neonatal exposure to a glyphosate-based herbicide (GBH) alters the reproductive performance and the molecular mechanisms involved in the decidualization process in adult rats. Newborn female rats received vehicle or 2 mg/kg/day of a GBH on postnatal days (PND) 1, 3, 5 and 7. On PND90, the rats were mated …
Abstract: Mineral nutrients are routinely applied to boost crop yields and improve overall plant health and quality. Their judicious use in production agriculture, horticulture, and environmental settings is critical for improved production efficiency and a sustainable ecosystem. The nutrition of a plant determines in large measure its resistance or susceptibility to disease, its histological or …
Abstract: Stable inheritance of the transgene, consistent expression and competitive agronomic properties of transgenic crops are important parameters for successful use of the latter. These properties have been analyzed with 18 homozygous transgenic barley lines of the cultivar Golden Promise. The lines originated from three independent primary transformants obtained by the biolistic method with three …
Abstract: The effects of glufosinate ammonium on embryonic development in mice were examined using whole embryo and micromass cultures of midbrain and limb bud cells. In day 8 embryos cultured for 48 hr, glufosinate caused significant overall embryonic growth retardation and increased embryolethality to 37.5% at 10 micrograms/ml (5.0 x 10(-5) M). All embryos in …
Abstract: Glufosinate ammonium, which is a component of the herbicide BASTA, is a phosphinic analog of glutamic acid. Its activity is related to the inhibition of glutamine synthetase. Previous studies demonstrated that glufosinate has no teratogenic potential in rats and rabbits in vivo. In the present study, we determined whether glufosinate could affect embryonic development …
Abstract: The frequency of gene flow from Brassica napus L. (canola) to four wild relatives, Brassica rapa L., Raphanus raphanistrum L., Sinapis arvensis L. and Erucastrum gallicum (Willd.) O.E. Schulz, was assessed in greenhouse and/or field experiments, and actual rates measured in commercial fields in Canada. Various marker systems were used to detect hybrid individuals: …
Abstract: A deregulation of programmed cell death mechanisms in human epidermis leads to skin pathologies. We previously showed that glyphosate, an extensively used herbicide, provoked cytotoxic effects on cultured human keratinocytes, affecting their antioxidant capacities and impairing morphological and functional cell characteristics. The aim of the present study, carried out on the human epidermal cell …
Abstract: The objective of this study was to evaluate whether standard fish meal diets prepared with increasing levels of genetically modified (GM; 150 and 300 g kg−1) maize (event MON810®) as a starch source, showed any nutritional or physiological adverse effects on Atlantic salmon, Salmo salar L. postsmolt. The diets with low or high inclusions of GM …
Abstract: Kalach 360 SL (KL), glyphosate (G) surfactant-based herbicides, is a systemic herbicide effective against weeds. It was applied in agriculture in Tunisia and throughout the world, which can represent a risk to non-target organisms. The aim of this study was to investigate the morphological and biochemical aspects of ovary injury after exposure to KL. …
Abstract: TT51, with a synthetic Cry1Ab/CryAc gene from Bacillus thuringiensis Berliner, was the first genetically modified (GM) plant officially certificated in China. This study was undertaken to investigate potential embryotoxicity of TT51 on rats. Whole embryo culture (WEC) is an effective method for safety evaluation when culture medium, containing substances derived from GM food, is …
Abstract: The analysis of the relevant part of the Institute of Nutrition Report showed that the studies were not carried out according to the accepted protocols for the biomedical assessment of GM food and feed (1). Many of the conclusions drawn by the authors do not correspond to the obtained data and therefore they are …
