Search Results for: Rats
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What types of studies are in the GMO Research Database? The GMO Research Database contains over 2,500 studies, surveys, and analyses that suggest various adverse impacts and potential adverse impacts of genetically engineered (GE/GMO) crops, foods and related pesticides. It contains references regarding health impacts, environmental impacts, impacts on non-target organisms (NTOs), resistance of target …
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Search the primary studies database using one of the pre-defined keyword searches below. # 2,4-Dichlorophenoxyacetic acid (2,4-D) 35S A Acetylcholinesterase Aegilops cylindrica Aflatoxin Africa African Catfish (Clarias Gariepinus) African clawed frog (Xenopus laevis) Agrobacterium Agroecology Agrostis Agrostis stolonifera Alfalfa (Medicago sativa) Allergy Alpaida Veniliae Amaranthus palmeri Amaranthus tuberculatus Ambrosia artemisiifolia Ambystoma gracile Ambystoma laterale Ambystoma …
Sex-dependent impact of Roundup on the rat gut microbiome
Abstract: A growing body of research suggests that dysbiosis of the gut microbiota induced by environmental pollutants, such as pesticides, could have a role in the development of metabolic disorders. We have examined the long-term effects of 3 doses of the Roundup(R) herbicide (made of glyphosate and formulants) on the gut microbiota in male and female …
Retraction by corruption: The 2012 Séralini paper
Abstract: On 19 September 2012 a paper written by the group led by G.-E. Séralini was published online and then in print in the November 2012 issue of Food and Chemical Toxicology. The study reported in the paper examined the effects on the health of rats of a genetically engineered maize, Monsanto’s NK603, and of …
Why glyphosate is not the issue with Roundup: A short overview of 30 years of our research
Abstract: Roundup and other glyphosate-based herbicides are the most widely used pesticides in the world; their residues are among the main pollutants in surface waters. Their use has increased through the spraying of 80% of edible agricultural GMOs, which also contain high levels of their residues. They are composed of glyphosate (35–40% in general) and adjuvants …
Conflicts of interests, confidentiality and censorship in health risk assessment: The example of an herbicide and a GMO
Abstract: We have studied the long-term toxicity of a Roundup-tolerant GM maize (NK603) and a whole Roundup pesticide formulation at environmentally relevant levels from 0.1 ppb. Our study was first published in Food and Chemical Toxicology (FCT) on 19 September, 2012. The first wave of criticisms arrived within a week, mostly from plant biologists without experience in toxicology. We …
Republished study: Long-term toxicity of a Roundup herbicide and a Roundup-tolerant genetically modified maize
Abstract: Background. The health effects of a Roundup-tolerant NK603 genetically modified (GM) maize (from 11% in the diet), cultivated with or without Roundup application and Roundup alone (from 0.1 ppb of the full pesticide containing glyphosate and adjuvants) in drinking water, were evaluated for 2 years in rats. This study constitutes a follow-up investigation of …
Conclusiveness of toxicity data and double standards
Text: We would like to comment on your answers (Hayes, 2014a) concerning the retraction of our study (Seralini et al., 2012, Hayes, 2014b) by Food and Chemical Toxicology (FCT). Our study investigated the long-term effects in rats of consumption of two Monsanto products, a genetically modified (GM) maize and its associated pesticide, Roundup, together and …
Genetically modified crop consumption at large scale: Possible negative health impacts due to holes in assessment. Overview of the safety studies of GMOs performed on mammals
Abstract: Recently, a debate on international regulation is ongoing on the capacity to predict and avoid adverse effects on health and environment of new products and novel food/feed (GMOs, chemicals, pesticides, nanoparticles …). The health risks assessment cannot avoid the study of blood analyses of mammals eating these products in subchronic or chronic tests. Mammalian …
New analysis of a rat feeding study with a genetically modified maize reveals signs of hepatorenal toxicity
Abstract: Health risk assessment of genetically modified organisms (GMOs) cultivated for food or feed is under debate throughout the world, and very little data have been published on mid- or long-term toxicological studies with mammals. One of these studies performed under the responsibility of Monsanto Company with a transgenic corn MON863 has been subjected to …
Neonatal exposure to a glyphosate based herbicide alters the development of the rat uterus
Abstract: Glyphosate-based herbicides (GBHs) are extensively used to control weeds on both cropland and non-cropland areas. No reports are available regarding the effects of GBHs exposure on uterine development. We evaluated if neonatal exposure to a GBH affects uterine morphology, proliferation and expression of proteins that regulate uterine organogenetic differentiation in rats. Female Wistar pups …
Effect of 2,4-dichlorophenoxyacetic acid on rat maternal behavior
Abstract: Exposure to 2,4-dichlorophenoxyacetic acid (2,4-D) has several deleterious effects on the nervous system such as alterations in the concentrations of neurotransmitters in the brain and/or behavioral changes, myelination rate, ganglioside pattern [Bortolozzi, A., Duffard, R., Antonelli, M., Evangelista de Duffard, A.M., 2002. Increased sensitivity in dopamine D(2)-like brain receptors from 2,4-dichlorophenoxyacetic acid (2,4-D)-exposed and …
Detection of 2,4-dichlorophenoxyacetic acid (2,4-D) residues in neonates breast-fed by 2,4-D exposed dams
Abstract: Knowing early nutritional status have been shown to be an important factor in determining the activity level of rats later in life, we studied offspring of dams which had received 50, 70 or 700 mg/kg of 2,4-Dichlorophenoxyacetic acid (2,4-D) during nursing. Neonatal tissues and the stomach content (milk) were examined up to 16 post …
Result of research of mutagenic activity of a genetically modified product in experiments on laboratory animals
Abstract: The aim of the research was assessment of mutagenic activity of the genetically modified product (a commercial product from soybean) in an experiment on laboratory animals. In the course of work in experienced groups the parameter of “unsuccessful” incubation of embryos in females of white not purebred rats is revealed. In control group the …
Glyphosate, pathways to modern diseases III: Manganese, neurological diseases, and associated pathologies
Abstract: Manganese (Mn) is an often overlooked but important nutrient, required in small amounts for multiple essential functions in the body. A recent study on cows fed genetically modified Roundup®-Ready feed revealed a severe depletion of serum Mn. Glyphosate, the active ingredient in Roundup®, has also been shown to severely deplete Mn levels in plants. …
An overview of the safety and biological effects of Bacillus thuringiensis Cry toxins in mammals
Abstract: Crystal proteins (Cry) produced during the growth and sporulation phases of Bacillus thuringiensis (Bt) bacterium are known as delta endotoxins. These toxins are being used worldwide as bioinsecticides to control pests in agriculture, and some Cry toxins are used against mosquitoes to control vector transmission. This review summarizes the relevant information currently available regarding the …
Perinatal exposure to a commercial formulation of glyphosate reduces the mRNA expression and increases the protein content of beta TSH in the pituitary of male offspring
Abstract: Glyphosate is a broad spectrum herbicide that is effective against weeds, especially in association with transgenic glyphosate resistant crop systems, and represents approximately 30% of all herbicides used in agriculture. It was demonstrated that glyphosate has an activity of endocrine-chemical disruptor (ECD) in the reproductive axis, altering the production of testosterone and causing disturbances …
Glyphosate impairs male offspring reproductive development by disrupting gonadotropin expression
Abstract: Sexual differentiation in the brain takes place from late gestation to the early postnatal days. This is dependent on the conversion of circulating testosterone into estradiol by the enzyme aromatase. The glyphosate was shown to alter aromatase activity and decrease serum testosterone concentrations. Thus, the aim of this study was to investigate the effect …
Prepubertal exposure to commercial formulation of the herbicide glyphosate alters testosterone levels and testicular morphology
Abstract: Glyphosate is a herbicide widely used to kill weeds both in agricultural and non-agricultural landscapes. Its reproductive toxicity is related to the inhibition of a StAR protein and an aromatase enzyme, which causes an in vitro reduction in testosterone and estradiol synthesis. Studies in vivo about this herbicide effects in prepubertal Wistar rats reproductive …
Carcinogenicity and toxicity of 2,4-dichlorophenoxy-acetic acid
Abstract: 2,4-Dichlorophenoxyacetic acid (2,4-D) is carcinogenic in male and female rats and probably also in mice. Male and female rats ingesting 2,4-D developed increased incidences of malignant neoplasms. Lymphosarcomas were increased in rats of both sexes, and neoplasms of the mammary gland in female rats. Male rats also had carcinomas of the endocrine organs. 2,4-D …
