Search Results for: Rats

Abstract: Recent studies demonstrate that glyphosate exposure is associated with oxidative stress and some neurological disorders such as Parkinson’s pathology. Therefore, phytochemicals, in particular phenolic compounds, have attracted increasing attention as potential agents for neuroprotection. In the present study, we investigate the impact of glyphosate on the rat brain following i.p. injection and the possible …

Abstract: Objective of this study was to determine the safety and quality parameters of transgenic corn (Ajeeb YG) compared with its near isogenic (Ajeeb). The PCR analysis showed the presence of 35S promoter and Cry1Ab gene sequences in the transgenic corn resulting in presence infectious CaMV35S which can cause disease, carcinogenesis, mutagenesis, reactivation of dormant …

Text: Unlike Walker and Lonsdale (2000), in Minnesota we don’t consider the debate on genetically modified organisms (GMOs) to be a “dialogue of the deaf.” Nor would we agree that the position of GMO proponents, i.e., the “scientists and technocrats,” is supported by “hard data,” while the “environmentalists” are the only ones making “alarmist claims.” …

Abstract: The 90-day animal study is the core study for the safety assessment of genetically modified foods in the SAFOTEST project. The model compound tested in the 90-day study was a rice variety expressing the kidney bean Phaseolus vulgaris lectin agglutinin E-form (PHA-E lectin). Female Wistar rats were given a nutritionally balanced purified diet with …

Abstract: Overproduction of reactive oxygen and nitrogen species can result from exposure to environmental pollutants, such as ionising and nonionising radiation, ultraviolet radiation, elevated concentrations of ozone, nitrogen oxides, sulphur dioxide, cigarette smoke, asbestos, particulate matter, pesticides, dioxins and furans, polycyclic aromatic hydrocarbons, and many other compounds present in the environment. It appears that increased …

Abstract: The incidence of infertility in human is on the increase and the use of Roundup herbicide and presence of its residues in foodstuff is a major concern. This study therefore aim to assess the effect of Roundup on the reproductive capacity of 32 adult male albino rats randomized into 4 groups of 8 rats …

Abstract: The potential toxicity of the herbicide Roundup and its fundamental substance (glyphosate) was tested in bioenergetic functions of isolated rat liver mitochondria. Roundup stimulates succinate-supported respiration twice, with simultaneous collapse of transmembrane electrical potential, while glyphosate used in the same concentrations does not induce any significant effect. Additionally, Roundup depresses state 3 respiration by …

Abstract: Genetically modified (GM) food crops are considered to have the potential of providing food security especially in developing countries. Scientists have raised concern over the hazards associated with the consumption of genetically modified organisms (GMOs). One of these hazards, which have great controversy reports, is the possible horizontal gene transfer from GM-food or feed …

Abstract: The aim of the study was to investigate the effect of genetically modified (GM) foods on alteration of hematological and biochemical parameters and effect on reproduction at experiment with white rats. It was found the difference between the tested and control groups: as the blood parameters as well the reproduction indexes of test group …

Abstract: The aim of this review is to examine the relationship between genetically modified (GM) crops and health, based on histopathological investigations of the digestive tract in rats. We reviewed published long-term feeding studies of crops containing one or more of three specific traits: herbicide tolerance via the EPSPS gene and insect resistance via cry1Ab …

Abstract: Genetically modified crops have been available for human and animal consumption since the 1990’s. Most crops have been modified to possess genes that either make them herbicide tolerant or insect resistant. Increasingly common though, are crops that possess both traits. Second to soy, corn is the most widely grown GM crop in the world1. …

Abstract: Glyphosate [N-(phosphonomethyl)-glycine] is a broad-spectrum, non-selective, post-emergence herbicide that is extensively used in agriculture. Published data referring to the effects of this product on human health are contradictory. We showed previously that long-term treatment of rats with low doses of Glyphosate-Biocarb® may induce hepatic histological changes and bleeding without decreasing platelet counts. The aim of …

Abstract: Lactose intolerance is characterized by low or inexistent levels of lactase, and the main treatment consists of dietary changes, especially replacing dairy milk by soy milk. Soy contains phytoestrogens, substances with known estrogenic activity, besides, glyphosate-based herbicides are extensively used in soy crops, being frequently a residue in soy beans, bringing to a concern …

Abstract: All approved genetically modified organisms (GMOs) are regarded as safe for daily human consumption. On the other hand, reports on possible hazards of GMOs have been circulated through various media. This study reviews the scientific literature on the health hazards of the Roundup Ready soybean and Bt-Maize crops. The toxicological assessment of the application …

Abstract: Pesticides may be involved in oyster summer mortality events, not necessarily as a single causative agent but as an additional stressor. In this context, the present study aimed to assess the toxicity of glyphosate, its by-product, aminomethylphosphonic acid (AMPA) and two commercial formulations, Roundup Express(®) (R(EX)) and Roundup Allées et Terrasses(®) (R(AT)), containing glyphosate …

Abstract: A 2-year rat feeding study with genetically modified NK603 maize sparked an international scientific and public debate as well as policy responses by the European Commission. The European Food Safety Authority (EFSA) evaluated the study as defective based on conceptual and methodological shortcomings by retroactive application of the recommendations of its recent guidance on …

Abstract: Commercial formulations of pesticides are invariably not single ingredients. Instead they are cocktails of chemicals, composed of a designated pesticidal “active principle” and “other ingredients,” with the latter collectively also known as “adjuvants.” These include surfactants, antifoaming agents, dyes, etc. Some adjuvants are added to influence the absorption and stability of the active principle …

Abstract: Background Glyphosate-based herbicides (GBH) are the major pesticides used worldwide. Converging evidence suggests that GBH, such as Roundup, pose a particular health risk to liver and kidneys although low environmentally relevant doses have not been examined. To address this issue, a 2-year study in rats administering 0.1 ppb Roundup (50 ng/L glyphosate equivalent) via …

Abstract: Background Glyphosate-based herbicides (GBH) are the major pesticides used worldwide. Converging evidence suggests that GBH, such as Roundup, pose a particular health risk to liver and kidneys although low environmentally relevant doses have not been examined. To address this issue, a 2-year study in rats administering 0.1 ppb Roundup (50 ng/L glyphosate equivalent) via …

Abstract: We are concerned about the characterization of the tested diet in the study of Delaney et al. (2014), investigating the subchronic health effects of the Roundup tolerant (DP-Ø73496-4) genetically modified canola on rats. The conclusion can be used by regulatory authorities. The presence of other Roundup tolerant GMOs and of Roundup herbicide residues were …

Abstract: Pesticides are used throughout the world as mixtures called formulations. They contain adjuvants, which are often kept confidential and are called inerts by the manufacturing companies, plus a declared active principle, which is usually tested alone. We tested the toxicity of 9 pesticides, comparing active principles and their formulations, on three human cell lines …

Abstract: In the matter of health issues, public policy is regularly shaken by health crises or unexpected scientific discoveries. This chapter overlooks pesticide toxicity, focusing on agricultural genetically modified organisms (GMOs) because they are essentially pesticide‐plants, designed to tolerate and/or produce new pesticide residues in food and feed. It also describes links between agricultural GMOs …

Abstract: Context – Among the 134 million hectares of genetically modified plants growing worldwide in 2009, more than 99.9 % are described as pesticide plants (Clive 2009). Around 80 % are tolerant to Roundup, a glyphosate based herbicide. Its use on GMOs is thus amplified, and this phenomenon shed a new light on the problem …

Text: In our lifetime we are experiencing never before seen rates of obesity, with a 68% rate of overweight in adults. In my field of gynecologic oncology, our surgical cases have become tremendously challenging due to the large size of our patients. When I was in residency training in the mid 1980s, it was rare …

Abstract: The effects of glyphosate oral exposure (35, 75, 150 and 800 mg/kg bw, 6 days) on brain region monoamine levels of male Wistar rats were examined. Glyphosate-treated rats (35, 75, 150 and 800 mg/kg bw, 6 days), had no visible injury, i.e., no clinical signs of dysfunction were observed. After last dose of glyphosate, …